摘要
采用热重法、微分热重法和差热分析法研究药物盐酸曲普利啶在空气流中的热氧降解历程及动力学，从而发现该药物的热氧降解过程由５个紧连步骤组成．用Ｃｏａｔｓ－Ｒｅｄｆｅｒｎ方程进行动力学处理，确定盐酸曲普利啶热氧降解的表观反应级数均为１．１，反应活化能分别为６６．５，１１３．７，１１６．２，１５３．８和１８０．６ｋＪ／ｍｏｌ．
DTA,TG,DTG techniques were used to study the thermal oxidation degradation and kinetics of triprolidine hydrochloride(C 19 H 22 N 2·HCl·H 2O) in air.It has been found that the thermal oxidation degradation of medicine C 19 H 22 N 2·HCl·H 2O is of five steps.Treated with Coats Redfern equation,the apparent degradation reaction orders of medicine C 19 H 22 N 2·HCl·H 2O are 1 1,the reactive energies are 66.5,113.7,116.2, 153.8, 180.6 kJ/mol.
出处
《中山大学学报（自然科学版）》
CAS
CSCD
北大核心
1998年第2期115-117,共3页
Acta Scientiarum Naturalium Universitatis Sunyatseni
关键词
盐酸曲普利啶
热氧降解
动力学
热稳定性
药物
triprolidine hydrochloride,thermal oxidation degradation, thermal oxidation degradation kinetics
