摘要
目的分析于2003～2007年收治呼吸道感染患者的病原菌的菌群分布及其耐药性变化,为临床合理用药提供依据。方法收集2003～2007年呼吸道感染患者的呼吸道标本作细菌培养、鉴定和药敏试验,依据CLSI颁布标准进行药敏试验结果判定,采用WHONET5.4软件进行数据分析。结果呼吸道病原菌以革兰阴性杆菌为主,其中铜绿假单胞菌的检出占比率最高,且铜绿假单胞菌和鲍曼不动杆菌的检出占比率逐年上升;革兰阳性球菌仍以葡萄球菌属多见。革兰阴性杆菌对阿米卡星、哌拉西林/他唑巴坦及头孢哌酮/舒巴坦尚有较高的敏感性;耐甲氧西林葡萄球菌的检出率逐年上升,未发现耐万古霉素和替考拉宁的葡萄球菌,葡萄球属对夫西地酸、氯霉素、米诺环素亦有较高的敏感率。结论呼吸道感染病原菌的分布及耐药性随年份而有一定变化,加强病原菌的耐药监测分析,对制订抗菌药物的使用策略具重要意义。
Objective To analyze the distribution and drug resistance of respiratory pathogens isolated from patients in a hospital in 2003-2007. Methods The samples were collected from patients with respiratory tract infection and pathogens were isolate and identified. Results Th.e majority of pathogens isolated from respiratory samples were gram-negative bacilli and Pseudomonas aeruginosa predominated. Staphylococci was predominated gram positive cocci . Imipenem and meropenem were the most sensitive antibiotics to gram-negative bacilli. But the resistance of Pseudomonas aeruginosa to imipenem showed an increasing trend. Imipenem-resistant Klebsiella pneumonia appeared in 2006 and 2007. The drug resistance of Escherichia cori and Klebsiella pneumonia also showed an increasing trend. Amikacin, piperacilhn-tazobactam and cefoperazone-tazobactam were still effective for gram-negative bacilli. No isolates of Staphylococci were resistant to vancomycin and teicoplanin. Staphylococci to fusidic acid, chloramphenicol and minocycline was also sensitive. Conclusions The distribution and drug resitance of the bacteria vary year after year and the work of monitoring be strengthened.
出处
《中国热带医学》
CAS
2009年第2期346-348,共3页
China Tropical Medicine
基金
2008年广州市医药卫生科技资助项目(2008-YB-174)
关键词
呼吸道感染
病原菌
耐药监测
敏感率
Respiratory tract infection
Pathogens
Resistance surveillance
Susceptible rate.
