摘要
目的了解和研究长期应用国产低剂量口服避孕药(OC)与使用者衣原体(CT)感染的关系。方法采用聚合酶链反应(PCR)检测服用避孕药或使用宫内节育器5年以上的妇女224人宫颈分泌物中CTDNA。结果三组研究对象的CT检出率为21.24%,三组中CT检出率1号片组最高,对照组最低,分别为1号片组24.69%、复方18甲组20.45%、对照组17.54%,服药组均高于对照组,CT检出率三组间的差别无显著性(P>0.05)。服药组不同类型的避孕药使用者中CT感染的检出率也不相同,1号片组CT感染高于复方18-甲组,这可能与COC中雌孕激素的配伍不同有关,1号片中的雌孕激素均高于复方18-甲组,与雌孕激素的共同作用而导致CT感染率增加。口服避孕药者中CT的感染引起的宫颈异常高于对照组,但无显著差异,多数感染者并无临床体征。结论长期服用避孕药者CT感染略有升高。对有性生活,特别是长期使用口服避孕药的妇女提供相应的随访和检测服务,以提高避孕药使用者的生殖健康水平。
Objective To understand the relationship between the long-term use of the combined oral contraceptives （COCs） and the Chlamydia trachomatis （CT） infection. Methods Polymerase chain reaction （PCR） was used to survey the infecton rate of CT in women long-term use combined norethisterone, combined norgestrel and worn IUD. Results The total detectable rate of CT was 21.24%. The detectable rate of CT in norethisterone group was the highest, and that of the control group is the lowest being 24.69% in the norethisterone group 20.45% in the norgestrel and 17.54% in the controls, respectively. The rates in the two COC groups were higher than that of the control group without significant difference （P〉 0.05）. Norethisterone contained a high amount of estrogen and progestin and the latters worked together resulting in the increased rate of CT infection. There no significant difference were observed among the three groups, but obvious clinical symptoms were observed in COC groups due to CT than that of the control group. However,most of CT positive women did not show any clinical symptoms. Conclusion COCs can result in the increase CT infection in COCs users. Some CT assay services should be provided for COC users to improve their reproductive health.
出处
《中国热带医学》
CAS
2009年第2期331-332,共2页
China Tropical Medicine
关键词
口服避孕药
衣原体
聚合酶链反应
Combined oral contraceptives
Chlamydia trachomatis
Polymerase chain reaction
