摘要
目的：寻求一种对多房棘球蚴易感和实验周期短的动物模型。方法：３种动物在实验感染多房棘球蚴原头节后不同时期剖检，观察多房棘球蚴在其体内的发育状况。结果：在感染后第９１ｄ剖检的３种动物平均湿囊重和囊重占体重的百分比分别为：灰仓鼠１５．０±２．１ｇ和３２．３％；子午砂土鼠３．３±１．１ｇ和６．９％；ＮＩＨ小鼠０．６±０．６ｇ和２．４％。第１８８ｄ时各为１１．８±２．７ｇ和２１．７％；８．１±５．１ｇ和１５．４％；８．４±８．３ｇ和２６．７％。灰仓鼠和子午砂土鼠在第９１ｄ时，原头节已发育成熟。而ＮＩＨ小鼠在１８８ｄ原头节才发育成熟。结论：灰仓鼠感染多房棘球蚴的易感性高于其他两种动物，其感染率高，囊泡发育佳，生长速度快。该鼠是感染多房棘球蚴的一种比较理想的实验动物。
AIM: To search for an animal model with higher susceptibility to Echinococcus multilocularis and shorter experimental period.METHODS: Cricetulus migratorius, Meriones meridianus and NIH mice were experimentally infected with protoscolices of E. multilocularis and were autopsed at different times after their infection. The development of E. multilocularis in these three species of rodents was observed and compared. RESULTS: The average wet cyst weight and the ratio of cyst weight to body weight on the 91st day after infection were 15 0±2 1 g and 32 3% for C.migratorius ,3 3±1 1 g and 6 9% for M. meridianus , 0 6±0 6 g and 2 4% for NIH mice; and the corresponding figures on the 188th day after infection were 11 8±2 7 g and 21 7% for C.migratorius , 8 1±5 1 g and 15 4% for M.meridianus and 8 4±8 3 g and 26 7% for NIH mice, respectively. On the 91st day, matured protoscolices were found in C.migratorius and M. meridianus , whereas NIH mice had matured protoscolices on the 188th day after infection.CONCLUSION: C. migratorius has higher sensitivity to E. multilocularis infection than the other two species of animals as manifested by high infection rate, well developed vesicles and rapid growth speed. C. migratorius proved to be an ideal experimental animal for E. multilocularis .
出处
《中国寄生虫学与寄生虫病杂志》
CSCD
北大核心
1998年第2期130-132,共3页
Chinese Journal of Parasitology and Parasitic Diseases
基金
新疆维吾尔自治区卫生厅青年基金
关键词
多房棘球蚴
灰仓鼠
子午砂土鼠
实验感染
Echinococcus multilocularis
Cricetulus migratorius
Meriones meridianus
NIH mice
experimental infection
