摘要
目的：探讨ＴＧＦβ１的表达与胃癌的关系及作用．方法：采用免疫组织化学方法，对４５例胃癌，２０例萎缩性胃炎伴中、重度肠腺化生及１５例正常胃粘膜组织进行了ＴＧＦβ１蛋白表达的检测．结果：胃癌组织ＴＧＦβ１表达明显增强，其阳性率（８００％）明显高于正常胃粘膜对照组（３３３％）及萎缩性胃炎组织（４００％），并具有显著的统计学意义（Ｐ＜００１）．但中、重度肠腺化生的萎缩性胃炎与正常对照组无显著差别．胃癌组织的分化程度越低，ＴＧＦβ１表达的阳性率越高．结论：ＴＧＦβ１的高表达在胃癌组织细胞恶性转化及增殖方面可能具有一定的生物学意义．
Aim:In order to investigate the relationship between the expression of TGFβ1 protein and gastric carcinoma Methods: The expression of TGFβ1protein was examined on human gastric cancer tissues(n=45), gastric mucosa in atrophic gastritis with mid or severe intestinal metaplasia(n=20) and normal gastric mucosa( n=15) by using immunohistochemistryResults:TGFβ1 protein expression in gastric cancer tissues was increased, and its positive rate( 800%) was significantly higher than that in normal gastric mucosa( 333%) and atrophic gastritis(400%) There was no significant difference between normal mucosa and atrophic gastritisMoreover, the degree of TGFβ1 protein expression was found to be related to the differentiation degree of gastric cancer tissue The lower the differentiation of gastric cancer tissue, the higher the expression of TGFβ1 protein Conclusion:TGFβ1 is involved in the gastric cancer cells proliferation and malignant transformation
出处
《第四军医大学学报》
1998年第1期31-33,共3页
Journal of the Fourth Military Medical University
关键词
胃肿瘤
转化生长因子
β1
免疫组织化学
stomach neoplasms transforming growth factorβ1 immunohistochemistry
