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血管内皮生长因子及其受体在肺损伤中作用的研究进展 被引量：7

Role of vascular endothelial growth factor and its receptors in ALI
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摘要 血管内皮生长因子(VEGF)既是一种多能性的生长因子,又是一种通透因子,在正常肺组织中大量表达,通过血管内皮生长因子受体(VEGFR)发挥其生理作用,具有促有丝分裂、血管生成和内皮细胞存活,增加血管通透性等作用,在急性肺损伤的发生、发展及转归中是一把双刃剑,其作用日益引起人们的重视。通过对VEGF在ALI/ARDS不同阶段中的作用的研究,有望为ALI/ARDS的药物治疗提供理论依据。 Vascular endothelial growth factor（ VEGF） as an angiogenic and chemotactic peptide, is a pluripotential endothelial cell growth and permeability factor, abundantly expressed in normal lung tissue, especially in alveolar and bronchial epithelium. It can induce mitochysis, angiogenesis, endothelial cell survival and enhance vascular permeability. It plays different roles in the different development stage of ALI/ARDS, which may provide a new clinical therapy for ALI/ARDS.
作者 张新红 王海龙
机构地区 北京解放军海军总医院呼吸科
出处 《中国急救医学》 CAS CSCD 北大核心 2008年第12期1135-1138,共4页 Chinese Journal of Critical Care Medicine
关键词 血管内皮生长因子 肺损伤 Vascular endothelial growth factor（ VEGF） Acute lung injury
分类号 R563.8 [医药卫生—呼吸系统]
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参考文献21

  • 1Hohnes DI, Zachary- I. Tile vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease [ J]. Genome Biol,2005,6(2) :209.
  • 2Shams N, Ianchulev T. Role of vascular endothelial growth factor in ocular angiogenesis[J]. Ophthahnol Clin North Am, 2006,19 ( 3 ) : 335 - 344.
  • 3Karkkainen MJ, Makinen T, Alitalo K. Lymphatic endothelium: a new frontier of metastasis research [J]. Nat Cell Biol, 2002,4 ( 1 ) : E2 - E5.
  • 4Stacker SA, Achen MG, Jussila L, et al. Lymphangiogenesis and cancer metastasis[J]. Nat Rev Cancer,2002,2(8) :573 -583.
  • 5Shibuya M. Differential roles of vascular endothelial growth factor receptor- 1 and receptor-2 in angiogenesis[J]. J Biochem Mol Biol, 2006,39(5 ) :469 -478.
  • 6Sotu K, Yamazaki Y, Marita T, et al. Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain - containing receptor but not to fms - like tyrosine kinase - I [ J ]. J Biol Chem, 2005,280(3) :2126 -2131.
  • 7Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors[J]. Nat Med, 2003,9(6):669-676.
  • 8Schoch HJ, Fischer S, Marti HH. Hypoxia - induced vascular endothelial growth factor expression causes vascular leakage in the brain [ J ]. Brain ,2002,125 ( Pt11 ) :2549 - 2557.
  • 9Mura M, dos Santos CC, Stewart D, et al. Vascular endothelial growth factor and related molecules in acute lung injury[ J]. J Appl Physio1,2004,97 (5) : 1605 - 1617.
  • 10Kazi AS, Lotfi S, Goncharova EA, et al. Vascular endothelial growth factor - induced secretion of fibronectin is ERK dependent [ J ]. Am J Physiol Lung Cell Mol Physiol, 2004,286 ( 3 ) : 1539 - 545.

二级参考文献27

  • 1陈劲龙,冉丕鑫.血管内皮生长因子与烟雾暴露所致大鼠肺气肿发病关系的研究[J].中华结核和呼吸杂志,2003,26(11):671-674. 被引量：22
  • 2刘博,刘雪燕,李娟,王伟,魏克伦.持续高氧暴露降低新生大鼠肺组织血管内皮生长因子的表达[J].中国当代儿科杂志,2005,7(5):447-450. 被引量：9
  • 3Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res, 2000, 55:15.
  • 4Thickett DR, Armstrong L, Millar AB.A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med, 2002,166(10):1332.
  • 5Tsokos M, Pufe T, Paulsen F, et al. Pulmonary expression of vascular endothelial growth factor in sepsis. Arch Pathol Lab Med, 2003,127(3):331.
  • 6Karmpaliotis D, Kosmidou I, Ingenito EP, et al. Angiogetic growth factor in the pathophysiology of a murine model of acutelung injury. Am J Physiol Lung Cell Mol Physiol, 2002,283(3):L585.
  • 7Mura M, dos Santos CC, Stewart D, et al. Vascular endothelial growth factor and related molecules in acute lung injury. Appl Physiol,2004,97(5):1605.
  • 8Dvorak HF, Brown LF, Detmar M,et al. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol, 1995,146(5):1029.
  • 9Rosenstein JM, Mani N, Silverman WF, et al. Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo. Proc Natl Acad Sci USA,1998,95(12):7086.
  • 10Heo JH, Lucero J, Abumiya T, et al. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia. J Cereb Blood Flow Metab, 1999,19(6):624.

共引文献19

同被引文献90

引证文献7

二级引证文献32

中国急救医学
2008年 第12期

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