摘要
目的：总结评价普罗帕酮治疗阵发性室上性心动过速的疗效及安全性。方法：40例阵发性室上性心动过速患者，在心电监护下，给予普罗帕酮70mg静脉注射，10min内注射完成；首剂未能转律者，再每10min静脉注射普罗帕酮35mg，最大累积用量不超过175mg。复律后给予口服普罗帕酮150-200mg，每日3次维持治疗。观察开始给药后的转复率及不良反应的发生情况。结果：31例（31／40，77．5％）首剂即转窦性心律，6例追加剂量后转为窦性心律，总有效率92．5％（37／40）。继续予口服普罗帕酮治疗半年以上，未见严重不良反应，未见复发者。结论：普罗帕酮治疗阵发性室上性心动过速，疗效显著且不良反应轻微。
Objective：To evaluate the therapeutic and side effect of paroxysmal supraventricular tachycardia （PSVT）. Methods：40 patients with PSVT were recruited. Under electrocardiogram and BP monitoring, propafenone was prescribed at first dose of 70rag by intravenous injection during 10 minutes. If the heart sinus rhythm couldn＇t be recovery after the first dose, 35 mg of propafenone could be duplicated after a 10 minutes interval and the maximum cumulative dosage was 175rag. After the heart sinus rhythm was recovery, oral propafenone was prescribed 150-200rng three times a day. All the patients were followed for response rate and relative side effect. Results： 31 cases （31/40, 77. 5%） were recovery to sinus rhythm after the first dose and 6 cases recovery after boost. The total response rate was 92. 5% （37/40）. Maintaining therapy for at least half year, there was no recurrence or serious side effect. Conclusion： Propafenone is effective and safe in treating PSVT.
出处
《医学理论与实践》
2009年第1期6-7,共2页
The Journal of Medical Theory and Practice
关键词
普罗帕酮
阵发性室上性心动过速
疗效
Propafenone, Paroxysmal supraventricular tachycardia （PSVT）, Effect
