摘要
目的观察1960—2007年山东省克山病病情及发病特点的动态变化，为克山病防治及科研提供依据。方法采用资料回顾方法，收集山东省各市（地）、县（市、区）、乡（镇）、村多层次防治网报告的每年克山病发病及死亡情况，收集1962、1969、1973、1982年4个年度进行的5次全省或大范围克山病流行病学调查及各病区县（市、区）流行病学调查结果，分析克山病发病特点。结果1960—2007年48年间全省共发现克山病患者4228例，年最高发病率为2．636／万（1587599368）。亚急型克山病当年病死率为88．0l％（492／559），慢型克山病5年病死率为67．91％（491／723）。全省发病经历了高发年、低发年、基本控制年3个阶段。1960—1979年为高发年，发现病人3969例，年最高发病率为2．636／万（158／599368）；1980—1989年为低发年，发现病人200例，年最高发病率为0．058／万（57／9908013）；1990—2007年为基本控制年，发现病人59例，年最高发病率为O．016／万（16／9720832）。克山病发病的基本变化特点是发病类型由急型、亚急型为主逐渐转变为慢型、潜在型为主；发病年龄由4—10岁为主逐渐转变为13～25岁及20岁以上为主；发病季节由3、4月份为高峰期逐渐转变为全年散在发生。结论山东省48年来克山病发病经历了3个阶段，大流行过后，发病呈逐年下降趋势，发病特点随病情的变化而演变。
Objective To observe dynamic changes of incidence and epidemic characteristics of Keshan disease（KSD） in Shandong Province from 1960 to 2007, in order to provide scientific basis for prevention and treatment. Methods The data below were collected and analyzed retrospectively. Morbidity and mortality of KSD were reported annually by multi-level prevention and treatment network at the level of province, city, county, township and village ; five large-scale epidemiological investigations of KSD were carried out in 1962, 1969, 1973, 1982 at province-scale and in every disease counties too. Results A total of 4228 cases of KSD occurred from 1960 to 2007 and the highest incidence rate was 2.636 per ten thousand（158/599 368） in Shandong Province. Mortality rate of sub-acute KSD was 88.01 percent（492/559） and the five years mortality rate of chronic KSD was 67.91 percent（491/723）. Incidence changes of KSD among 48 years experienced three stages （the years of the high and low incidence, the years with basically controlled incidence） in Shandong Province. The years of high incidence were from 1960 to 1979, when 3969 cases of patients were found, its highest incidence rate being 2.636 per ten thousand （158/599 368）. The years of low incidence were from 1980 to 1989, when 200 cases of patients were found, the highest incidence rate being 0.058 per ten thousand（57/9 908 013）. In the years from 1990 to 2007 the disease was basically controlled, and only 59 cases of patients were found, with the highest incidence rate of 0.016 per ten thousand （16/9 720 832）. KSD onset gradually changed from acute and sub-acute to chronic and potential type. The onset age were gradually from 4 - 10 years old to 13 - 25 years old and 20-year-old and above. The disease was sporadically seen around the whole year instead of peaking in March and April. Conclusions The incidence of KSD has experienced the high, the low and controlled stages for the past 48 years in Shandong Province, which has decreased gradually after a major prevalence. The onset characteristics evolves with incidence changes.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2009年第1期81-84,共4页
Chinese Jouranl of Endemiology
基金
基金项目：山东省科学技术发展计划项目（2008GG10002053）
关键词
克山病
发病率
流行病学
Keshan disease
Incidence
Epidemiology
