转移性肾细胞癌靶向治疗进展
摘要
肾细胞癌起病隐匿,约20%~30%的患者在就诊时已发生远处转移,局限性肾癌行根治术后亦有30%~40%会发生转移。对转移性肾癌尚无标准治疗方案。随着肿瘤学研究的不断深入,相继有索拉非尼、舒尼替尼、Bevacizumab和Temsimlimus等分子靶向药物应用临床并取得良好的临床效果。现将其临床试验结果、不良反应以及在非透明细胞癌中的应用等方面最新进展作一综述。
出处
《国际泌尿系统杂志》
2009年第1期74-77,共4页
International Journal of Urology and Nephrology
参考文献22
-
1Patard JJ, Pouessel D, Bensalah K. Targeted therapy in renal cell carcinoma. World Journal of Urology, 2008,26(2) :135 - 140.
-
2Motzer RJ, Mazumdar M, Bacik J, et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol, 1999,17 ( 8 ) :2530 - 2540.
-
3张雨涛,陈铌,曾浩,周桥.肿瘤抑制基因VHL、低氧诱导因子与肾细胞癌[J].中华病理学杂志,2006,35(9):562-564. 被引量:6
-
4Spronsen DJ, Mulders PF, Mulder PH,et al. Novel treatments for metastatic renal cell carcinoma. Crit Rev Oncol Hematol, 2005,55 (3) : 177 - 191.
-
5Mendel DB, Laird AD, Xin X, et al. In vivo anti -tumor activity of SU11248, a novel tyrosine kinase inhibitor targeting VEGF and PDGF receptors: Determination of a pharmacokinetic/ pharmacodynamic relationship. Clin Cancer Res, 2003, 9:327-337.
-
6Motzer RJ. Sunitinib versus interferon alfa in metastatic renal - cell carcinoma. New England Journal of Medicine, 2007,356 (2):115 - 124.
-
7Motzer RJ. Sunitinib versus interferon ( IFN ) - alfa as first - line treatment of metastatic renal cell carcinoma (mRCC) : updated efficacy and safety results and further analysis of prognostic factors. Ejc Supplements,2007,5 (4) : 301 - 310.
-
8Patard JJ, Rioux - Leclercq N, Fergelot p. Understanding the importance of smart drugs in renal cell carcinoma. Eur Urol, 2006, 49:633 -643.
-
9Bukowski RM, Eisen T, Szczylik C. Final results of the randomized phase Ⅲ trial of sorafenib in advanced renal cell carcinoma, survial and biomarker analysis. J Clin Oncol 2007,25 (Suppl) :240s.
-
10Szczylik C, demkow T, Staehler M. Radomised phase Ⅱ trial of first - line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: Final results. J Clin Oncol, 2007,25 (Suppl) :241 s.
二级参考文献30
-
1龚侃,张宁,那熙,吴关,杨新宇,辛殿祺,那彦群.散发性肾透明细胞癌组织中希佩尔林道基因突变与缺氧诱导因子1α、2α的测定[J].中华外科杂志,2005,43(6):390-393. 被引量:3
-
2Latif F,Tory K,Gnarra J,et al.Identification of the von Hippel-Lindau disease tumor suppressor gene.Science,1993,260:1317-1320.
-
3Eble JN,Sauter G,Sesterhen IA,et al,eds.World Health Organization classification of tumours.Pathology and genetics of the urinary system and male genital organs.Lyon:IARC Press,2004.15-17.
-
4Maxwell PH,Weisner MS,Chang GW,et al.The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.Nature,1999,399:271-275.
-
5Lee JW,Bae SH,Jeong JW,et al.Hypoxia-inducible factor (HIF-1) alpha:its protein stability and biological functions.Exp Mol Med,2004,36:1-12.
-
6Maynard MA,Ohh M.Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer.Am J Nephrol,2004,24:1-13.
-
7Iliopoulos O,Ohh M,Kaelin WG Jr.pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation.Proc Natl Acad Sci U S A,1998,95:11661-11666.
-
8Min JH,Yang H,Ivan M,et al.Structure of an HIF-1[alpha] -pVHL complex:hydroxyproline recognition in signaling.Science,2002,296:1886-1889.
-
9Jaakkola P,Mole DR,Tian YM,et al.Targeting of HIF-[alpha] to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.Science,2001,292:468-472.
-
10Hirsila M,Koivunen P,Gunzler V,et al.Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.J Biol Chem,2003,278:30772-30780.
共引文献5
-
1宋德刚,王哲海.转移性肾细胞癌分子靶向治疗研究进展[J].中国肿瘤临床,2007,34(10):594-597. 被引量:5
-
2崔旭(综述),谢泽铨(综述),庄惠强(综述),杨泽松(综述),叶烈夫(综述).CA9与其相关基因及其产物在肾细胞癌诊断与治疗方面应用的研究现状[J].国际泌尿系统杂志,2010,30(2):199-203.
-
3赵志强,王养民,张斌,景德善,常德辉,鲁守琳,赵玉海.散发性嗜铬细胞瘤中希佩尔林道蛋白与缺氧诱导因子-α的相关性研究[J].现代肿瘤医学,2010,18(8):1581-1583.
-
4宋小莉,苏娟,刘重阳,张广源,张鑫.类风湿关节炎滑膜组织中脯氨酸羟化酶及希佩尔林道肿瘤抑制蛋白的表达及意义[J].中国组织工程研究,2019,23(23):3623-3629. 被引量:10
-
5郭瑞锋,马达.m^(6)A甲基化修饰在透明细胞肾细胞癌中的研究进展[J].医学综述,2023,29(24):5661-5668. 被引量:1
-
1杨东平,孙震鹏,周平.手术治疗肾细胞癌31例临床分析[J].吉林医学,1996,17(4):217-218.
-
2燕翠菊,黄备建.色素性肾细胞肿瘤超声表现1例[J].中国超声医学杂志,2011,27(11):1057-1057.
-
3胡俊松,万严.肾癌的CT诊断与病理表现(附10例分析)[J].江西医药,2008,43(10):1096-1097. 被引量:1
-
4刘禄明,刘芳.肾嗜酸细胞腺瘤与嫌色细胞癌的CT鉴别诊断[J].医学影像学杂志,2013,23(4):639-640. 被引量:6
-
5耿敬姝,刘美娜.肾细胞癌微血管形态特征及P_(21)蛋白的表达[J].哈尔滨医科大学学报,1997,31(5):374-376.
-
6熊磊,甘卫东,樊祥山.微血管密度与肾细胞癌预后关系的研究进展[J].中华腔镜泌尿外科杂志(电子版),2016,10(4):60-64. 被引量:1
-
7付国庆,范林妮,尹志勇,李培峰,刘一雄,朱瑾,张月华,王哲.肾细胞癌中RSK4的表达及其与患者临床病理特征的相关性[J].临床与实验病理学杂志,2013,29(2):141-146. 被引量:4
-
8邹学森.肾细胞癌IL-6高表达与预后和治疗[J].江西医药,1997,32(6):369-370.
-
9钱立新.肾癌类固醇激素受体表达及其内分泌治疗进展[J].国外医学(泌尿系统分册),1996,16(5):203-206. 被引量:1
-
10杜薇,姚丽青.脑转移性管状囊性肾细胞癌1例并文献复习[J].临床与实验病理学杂志,2017,33(3):330-332. 被引量:2