摘要
目的:观察联合应用阿托伐他汀与依折麦布治疗对严重高胆固醇血症患者的降脂疗效。方法:40例严重高胆固醇血症患者用阿托伐他汀(20mg.d-1)治疗后低密度脂蛋白胆固醇(LDL-C)未达标(<2.6mmol.L)的患者联合应用依折麦布(10mg.d-1),观察治疗12周后的血脂水平,并观察对谷转氨酸(AST)、谷丙转氨醇(ALT)和肌酸激醇(CK)的影响。结果:全部患者的基线总胆固醇(TC)、低密度脂蛋白的胆固醇(LDL-C)、三酰甘油(TG)、载脂蛋白B(ApoB)、脂蛋白[α(Lp(a))]在服用阿托伐他汀后均有明显降低,高密度脂蛋白的胆固醇(HDL-C)有明显上升,P<0.01。联用依折麦布后,TC、LDL-C、ApoB有进一步的下降,P<0.01,TG、HDL-C和Lp(a)虽有下降但无统计学差异。治疗前后AST、ALT和CK均无明显异常变化。结论:阿托伐他汀联合应用依折麦布对高胆固醇血症患者有更好的降脂(LDL-C)效果,并提高降脂达标率。
Objective：To investigate the efficacy of atorvastatin combined with ezetimibe in the treatment of patients with hypercholesterolemia. Methods：Forty patients （23 males, 17 females, aged 58 -± 12 yrs） with severe hypercholesterolemia who failed to achieve lipid lowering target level （LDL-C〈2.6 mmool/L） after 6 months treatment with atorvastatin （20mg, Qd） were added with ezetimibe （10 mg, Qd） for 3 months observation. Results： After 6 months treatment with atorvastatin, the lipids of TC, LDL-C,TG,ApoB and Lp（a） were decreased and HDL C elevated remarkably than those at baseline, and with P 〈0.01 respectively. When combined with ezetimibe for 3 months, the lipid level of TC, LDL C and ApoB was reduced than that of merely using atorvastatin, and with P〈0. 01 in respect. No significant abnormalities were found in particular with AST, ALT and CK during this therapy. Conclusion： Atorvastatin combined with ezetimibe can produce further lipid lowering effects than only atorvastatin in patient with severe hypercholesterolemia.
出处
《中国临床医学》
北大核心
2008年第6期768-769,共2页
Chinese Journal of Clinical Medicine
