摘要
一些经过糖基修饰合成的前体药物表现出良好的抗病毒、抗肿瘤与镇痛活性。利用D-核糖对扑热息痛的结构进行了修饰,设计合成了一种具有潜在生理活性和药物缓释功能的糖苷类化合物1-O-(4-乙酰氨基苯基)--βD-呋喃核糖苷,总收率70%。目标化合物及其中间体结构经1HNMR1、3CNMR、元素分析和IR确认。
Some prodrugs modified with glycoside exhibit good activity in antivirus, antitumor and analgesic effect. 1- O-（ 4-acetaminophenyl）-β-D-ribofuranoside with a potential biological activity and sustained-release function was synthesized in 70% yield. The structure of target compound and its intermediates were confirmed by ^1H NMR, ^13CNMR, elemental analysis and IR spectrometry.
出处
《化学试剂》
CAS
CSCD
北大核心
2009年第1期17-19,共3页
Chemical Reagents
关键词
扑热息痛
核糖
修饰
缓释
paracetamol
ribose
modification
sustained-release
