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OPN及β-catenin在涎腺黏液表皮样癌中的表达及意义 被引量：2

Expression of β-catenin and Osteopontin in Mucoepidermoid Carcinoma.
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摘要 目的:研究OPN及β-catenin在黏液表皮样癌中的表达,探讨其在黏液表皮样癌病变中的作用及其临床意义。方法:应用免疫组织化学S-P法检测35例黏液表皮样癌及12例正常涎腺组织中β-catenin及OPN的表达。结果:黏液表皮样癌中β-catenin和OPN的阳性表达率分别为37.1%(13/35)和65.7%(23/35)与正常对照组存在显著性差异(P<0.05)。在黏液表皮样癌中它们的表达呈显著相关性(P=0.0001,R=-0.691)。β-catenin和OPN的阳性率在不同分化程度的黏液表皮样癌中存有差异(P<0.05),且与是否存在淋巴结转移有显著性关系(P<0.05)。结论:β-catenin及OPN的表达与黏液表皮样癌的发生和发展关系密切,检测该指标有助于判断黏液表皮样癌的病理分级和淋巴结转移的关系。 Objective： To detect the expression of β- catenin and osteopontin （OPN） in mucoepidermoid carcinoma （MEC） and explore its clinicopathological significance. Methods ： SP immunohistochemical staining of β - eatenin and OPN was carried out in 35 cases of MEC and 12 cases of normal salivary tissues. Results： The positive rates of β - catenin and OPN were 37.1% （13/35） and 65.7% （23/35）. Correlationship was shared by positive β -eatenin and OPN in MEC （P =0.0001 ,R = -0. 691 ）. There were significant differences for β - catenin and OPN positive rates in different grades of MEC and the positive rates were related with lymph node metastasis （ P 〈 O. 05 ）. Conclusion： There was significant correlation between the expression of β - catenin and OPN and the WHO pathologic grade of mucoepidermoid carcinoma, which may indicate the clinic prognostic significance.
作者 赛音乌力吉 吕克文 赵尔扬
机构地区 哈尔滨医科大学附属口腔医学院口腔颌面外科 哈尔滨医科大学附属口腔医学院口腔组织病理教研室
出处 《口腔医学研究》 CAS CSCD 2008年第6期640-643,共4页 Journal of Oral Science Research
关键词 黏液表皮样癌 Β-CATENIN OPN免疫组织化学 Mucoepidermoid carcinoma β - catenin OPN Immunohistochemistry
分类号 R739.87 [医药卫生—肿瘤]
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二级参考文献96

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共引文献20

同被引文献13

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二级引证文献9

口腔医学研究
2008年 第6期

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