摘要
目的探寻川芎嗪注射液治疗急性期脑出血大鼠的时间窗。方法大鼠随机分为假手术组、模型组、6h、12h、24h、36h治疗组,造模后予以相应处理;观察大鼠神经功能障碍、出血区脑组织病理形态,检测血肿体积。结果与模型组相比,12h、24h、36h治疗组大鼠神经功能障碍减轻,血肿体积减小,尤以12h治疗组降低最为明显;6h治疗组大鼠神经功能障碍加重,出血坏死灶扩大。结论川芎嗪注射液在一定时间窗可减轻急性期脑出血大鼠脑水肿,减小血肿体积,其作用可能与降低水通道蛋白和胶质纤维酸性蛋白的表达有关。
Objective： To study the time- windows of ligustrazinge injection in rats with acute cerebral hemorrhage. Methods： The model of acute cerebral hemorrhage was established by injecting collagenase into the caudate nucleus of the rat. The rats were randomly divided into 6 equal groups ： sham operation group, model group and 6h, 12h, 24h and 36h treatment group. The histopathologieal changes in the brain tissue, neurological dysfunction and eubage of the hematoma were detected. Results： Compared with model group, the degree of dysfunction of the neuron of rats with acute cerebral hemorrhage and the cubages of the hematoma were decreased in ligustrazinge 12h, 24h, 36h treatment groups. Such effects were showed more apparent in 12h treatment group, while the degree of dysfunction of the neuron was aggravated and the cubages of hematoma were increased in 6h treatment group. Conclusion： Ligustrazinge injection can alleviate cerebral edema and decrease the cubages of the hematoma of the acute cerebral hemorrhage rat in certain time - windows, which might be realized by depress the expression of AQP4 and GFAP.
出处
《中国中医急症》
2009年第1期81-82,92,共3页
Journal of Emergency in Traditional Chinese Medicine
关键词
脑出血
川芎嗪
时间窗
大鼠
Cerebral hemorrhage
Ligustrazinge
Time- windows
Rats
