摘要
目的:建立测定盐酸雷诺嗪中有机溶剂残留的顶空毛细管气相色谱法。方法:DB-624柱(固定液:6%氰丙基苯基- 94%二甲基聚氧硅烷)(30m×0.32mm×1.8μm);氢火焰离子化检测器(FID),程序升温。结果:7种溶剂甲醇、乙醇、乙醚、二氯甲烷、乙酸乙酯、1,4-二氧六环、甲苯在此条件下能有效分离,且线性关系良好。平均回收率为98.1%-105.5%,RSD为1.1～3.7%(n=6)。结论:方法简单,准确,灵敏,适用于盐酸雷诺嗪中有机溶剂残留物的测定。
To establish a mathod for determination of residual organic solvents in ranolazine dihydrochloride by Headspace gas chromatographys. Method： DB-624 capillary column（30m×0.32μm ×1.8μm） was used, the detector was FID, the column temperature was programmed temperature. Result： Seven residual origanie solvents were completely separated. The calibration curves of the seven solvents were linear, the average recoveries were 98.1% - 105.5 % with RSD 1.1 - 3.7% （ n = 6）. Conclusion ： The meth- od is simple, accurate and sensitive,it can be used for the detemination of residual organic solvents in ranolazine dihydrochloride.
出处
《中国药师》
CAS
2009年第1期84-86,共3页
China Pharmacist
关键词
盐酸雷诺嗪
有机溶剂残留
项空气相色谱法
Ranolazine Dihydrochloride
Residual organic solvents
Headspace Gas chromatography
