摘要
（目的）研究食管小细胞癌（SCCE）的临床病理特征。（方法）通过对13例SCCE的病理形态分析和免疫组化SAP法EMA、NSE、Cytokeratin、ChromograninA、Synaptophsin检测。〔结果）病理组织学分为小圆、燕麦细胞到6例，中间型2例，混合型3型，基底细胞样型2例。全组免疫组化上皮和神经内分泌标记均显示较高双向表达的检出率。随访6例中5例（83％）死于诊治后1年内。（结论）SCCE是一种生长迅速，侵袭性强，恶性度高，预后差，且具有多向分化增能特征的神经内分泌癌，应与一般食管癌相区分。
(Purpose ) To study the clinical pathologic character of small cell carcinoma of esophageal (SCCE)To analyse the histological type classification and immunohistochemical staining of EMA、NSE、Cytokeratin、Chromogranin A,Synaptophsin by SAP method in 13 cases of SCCE.(Results)Histological type classification:small round oat -like cell type 6cases;median type 2 cases;mixed type 3 cases;basal cell-like type 2cases. Immunohistochemical staining showed high positive rates of both epithelial and neuroendocrine expression in all 13 cases of SCCE. In 6 follow-up cases,5 cases(83%) were dead in no more than one year after diagnosis and treatment.(Conclusions) SCCE is one of neuroendocrine carcinoma,which has high degree malignancy,strong invasion,poor prognosis and multiple differentiation potential. It ought to differ from other esophageal carcinoma.
关键词
食管肿瘤
小细胞癌
组织病理
免疫组化
Esophageal neoplasms Small cell carcinoma Histopathology Immunohistochemistry
