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腺苷负荷^13N—NH3 PET心肌灌注显像结合冠状动脉CTA诊断冠心病 被引量:6

Integration of ^13N-NH3 PET myocardial perfusion imaging and coronary CT angiography in the diagnosis of coronary artery disease
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摘要 目的评价腺苷负荷^13N-NH3 PET心肌灌注显像(MPI)与CT冠状动脉造影(CTA)相结合对提高冠心病(CAD)诊断准确性的临床应用价值。方法对25例怀疑CAD的患者同时行腺苷负荷^13N-NH3 MPI及CTA,1个月内行导管法冠状动脉造影(CAG)。结果(1)25例患者共300个冠状动脉节段,CTA显示良好节段为263个,显示率(显示良好节段所占百分比)达87.7%。(2)25例患者CTA、MPI及CTA+MPI诊断CAD的灵敏度、特异性、准确性、阳性预测值及阴性预测值分别为82.1%(23/28),87.5%(14/16)及93.8%(15/16);93.2%(219/235),8/9及9/9;92.0%(242/263),88.0%(22/25)及96.0%(24/25);58.9%(23/293,93.3%(14/15)及100.O%(15/15);97.8%(219/224),8/10及9/10。结论PET/CT实现了同机腺苷负荷^13N—NH3 PET心肌灌注显像与CTA相结合,提高了诊断CAD的准确性。 Objective An accurate, noninvasive technique for the diagnosis of coronary artery disease (CAD) should provide complementary information on coronary anatomy and pathophysiology of lesions. This paper present the results of integrated PET/CT for combined acquisition of coronary anatomy and myocardial perfusion for the diagnosis of CAD. Methods On a PET/CT scanner, contrast enhanced CT angiography (CTA) and rest/adenosine-stress myocardial perfusion imaging (MPI) with ^13N ammonia were performed on 25 patients who were suspected of having CAD. All these patients underwent selective coronary angiograph (CAG) within one month of PET/CT study. Results Of the 300 coronary artery segments in 25 patients, 263 coronary artery segments were considered possible to be evaluated by CTA (87.7%). In the 25 patients, the sensitivity, specificity, accuracy, positive and negative predictive values of CTA alone, PET (MPI) alone and PET (MPI) plus CTA were 82.1% (23/28), ,87.5% ( 14/16), 93.8% ( 15/ 16) ; 93.2% (219/235), 88.9% (8/9) and 100.0% (9/9) ; 92.0% (242/263), 88.0% (22/25) and 96.0% (24/25) ; 58.9% (23/29), 93.3% (14/15) and 100.0% (15/15) ; 97.8% (219/224), 80% (8/10) and 90% (9/10), respectively. Conclusion Combination of PET and CTA are superior to either CAT alone or PET alone in diagnosis of CAD.
出处 《中华核医学杂志》 CAS CSCD 北大核心 2008年第6期365-368,共4页 Chinese Journal of Nuclear Medicine
基金 福建省青年科技人才创新项目(2005J070)
关键词 冠状动脉疾病 体层摄影术 发射型计算机 体层摄影术 X线计算机 冠状血管造影术 腺苷 NH3 Coronary disease Tomography, emission-computed Tomography, X-ray computed Coronary angiography Adenosine NH3
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