摘要
目的:探讨联用超声波治疗对脑梗死患者急性期血浆D-二聚体(D-dimer)含量的影响。方法:发病24h内入院的急性脑梗死患者120例,随机分为超声波组及常规组各60例,均接受神经内科常规药物治疗,超声波组同时联用超声波治疗。2组患者在入院时及治疗3周后进行血浆D-dimer的检测及神经功能缺损评分评定临床疗效;同时选取88例正常健康体检者(健康组)作为阴性对照。随访1年,将死亡及再发卒中记录为终点事件对患者生存曲线进行分析。结果:治疗4周后,超声波组与常规组D-dimer含量与治疗前比较均明显下降(P<0.05),与常规组比较,超声波组下降速度更明显;但仍高于健康组(P<0.05)。临床疗效评定,超声波组总有效率明显高于常规组(91.7%与73.3%,P<0.05);比较2组生存曲线发现,超声波组终点事件发生率明显低于常规组(11.7%与31.7%,P<0.05)。结论:急性脑梗死辅以超声波治疗可明显降低血浆D-dimer含量和神经功能缺损程度。
Objective：To investigate the effects of ultrasonic wave therapy on the content of plasma D-dimer in patients with acute cerebral infarction （ACI）. Methods： All 120 patients with ACI within the first 24 h from stroke onset were randomly divided into the control group and therapy group equally. All patients received routine treatment, and those in the therapy group were subjected to cerebral ultrasonic wave therapy additionally. In both groups, the blood Ddimer contents were measured at the time of admission and 3 weeks later. According to Neurological Impairment Scale scores （NIS）, the prognosis was evaluated at the time of admission and 3 weeks later. Eighty-eight health medical exam- iners served as the negative control group. Results：The D-dimer contents were significantly lower after therapy than before therapy in each group （P〈0.05）, and lower in the therapy group than in the control group （P〈0.05）. Survival analysis showed the patients in the therapy group had a better prognosis （log-rank test, P〈0.05）. Conclusion：The ultrasonic wave can reduce the content of plasma D-dimer in patients with ACI.
出处
《中国康复》
2008年第6期394-395,共2页
Chinese Journal of Rehabilitation
基金
武汉市科技攻关项目[武卫(2005)294-27]
关键词
超声波
脑梗死
血浆D-二聚体
ultrasonic wave
cerebral infarction
plasma D-dimer
