摘要
为探讨CD4＋CD25＋调节性T细胞作为细胞疫苗抑制小鼠同种异体胰岛移植物排斥反应的作用，采用免疫磁珠分离技术分选CD4＋CD25＋调节性T细胞联合BALB／cByJ小鼠同种异体胰岛移植。结果显示，CD4＋CD25＋调节性T细胞可明显延长同种异体移植物的存活时间。
The potential effect of donor CD4＋CD25＋ regulatory T cells on the suppression of rejection for allogenetic islet transplantation in vivo was investigated. CD4＋CD25＋ regulatory T cells were generated by magnetic activated cell sorting and were allogeneically transfered with islet transplantation in streptozotocin-induced diabetic BALB/cByJ mice. The results showed that allogeneic CD4＋CD25＋ regulatory T cells prolong islet graft survival and normoglycemia in transplanted allogeneic diabetic mice.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2008年第6期661-663,共3页
Chinese Journal of Endocrinology and Metabolism
基金
基金项目：江苏省政府医学重点学科项目基金（苏卫科教2001-34）
关键词
T淋巴细胞
调节性
胰岛移植
免疫耐受
T-lymphocytes, regulatory
Islets of Langerhans transplantation
Immune tolerance
