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罗格列酮对糖基化终产物干预的人肾系膜细胞fractalkine表达的影响 被引量：5

On the expression of fractalkine by rosiglitazone in human renal mesangial cells induced by advanced glycation end products
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摘要 观察罗格列酮和糖基化终产物对人肾系膜细胞fractalkine（FKN）表达的影响。结果显示糖基化终产物能上调人肾系膜细胞的FKN表达，而罗格列酮能抑制糖基化终产物引起的FKN表达增加。 The effect of rosiglitazone and advanced giycation end products （AGEs） on the expression of fractalkine in cultured human renal mesangial ceils （HRMC） were investigated. Rosiglitazone inhibits the upregulation of fractalkine induced by AGEs in HRMC.
作者 魏琼 董莉 孙子林 刘必成 刘乃丰
机构地区 东南大学附属中大医院
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2008年第6期660-661,共2页 Chinese Journal of Endocrinology and Metabolism
基金 基金项目：江苏省中医药管理局（H05119） 东南大学新进博士启动基金（9290002258） 东南大学科技基金（2003YJ39）
关键词 糖基化终产物 高级 FRACTALKINE 糖尿病肾病 罗格列酮 Glycosylation end products, advanced Fractalkine. Diabetic nephrooathies： Rosiditazone
分类号 R587.2 [医药卫生—内分泌]
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参考文献7

  • 1Thomas MC, Forbes JM, Cooper ME. Advanced glycation end products and diabetic nephropathy. Am J Ther, 2005,12:562-572.
  • 2Katherine RT. Linking metabolism and immunology : diabetic nephropathy is an inflammatory disease. J Am Soc Nephrol, 2005,16: 1537-1538.
  • 3Sun ZL. AGE induce the expression of monocyte chemoattractant protein- 1 in human renal mesangial cells. Diabetologia, 2002,45:A394.
  • 4Kikuchi Y, Imakiire T, Hyodo T, et al. Advanced glycation end-product induces fractalkine gene upregulation in normal rat glomeruli. Nephrol Dial Transplant, 2005,20:2690-2696.
  • 5Kikuchi Y, Ikee R, Hemmi N, et al. Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. Nephron Exp Nephrol, 2004,97 :e17-e25.
  • 6Moraes LA, Piqueras L, Bishop BD. Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther, 2006,110:371-385.
  • 7李慧,邹大进,贾一韬,韦多,季军捷,彭玲.罗格列酮对高糖诱导的大鼠系膜细胞NF-κB活性及MCP-1表达的抑制作用[J].中华内分泌代谢杂志,2005,21(5):469-470. 被引量：7

二级参考文献5

  • 1Wada T, Yokoyama H, Matsushima K, et al. Monocyte chemoattractant protein-1: dose it play a role in diabetic nephropathy? Nephrol Dial Transplant, 2003,18:457-459.
  • 2Ha H,Yu MR,Choi YJ, et al. Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells. J Am Soc Nephrol, 2002,13:894-902.
  • 3Cernuda-Morollon E, Rodriguez-Pascual F, Klatt P, et al. PPAR agonists amplify iNOS expression while inhibiting NF-κB:Implications for mesangial cell activation by cytokines. J Am Soc Nephrol, 2002,13:2223-2231.
  • 4Aljada A, Garg R, Ghanim H, et al. Nuclear factor-κB suppressive and inhibitor-κB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antinflammatory action? J Clin Endocrinol Metab, 2001,86:3250-3256.
  • 5Panzer U, Schneider A, Guan Y, et al. Effects of different PPAR-agonist on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis.Kidney Int, 2002,62:455-464.

共引文献6

同被引文献65

引证文献5

二级引证文献21

中华内分泌代谢杂志
2008年 第6期

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