摘要
目的观察不同剂量雷公藤多苷治疗肾移植术后蛋白尿的临床效果。方法选择肾移植术后出现蛋白尿患者45例,按随机数字法分为3组,足量雷公藤多苷组(常规组)、半量雷公藤多苷组(半量组)、对照组各15例。常规组在应用免疫抑制剂基础上用雷公藤多苷1mg/(kg·d)治疗。半量组在应用免疫制剂基础上用雷公藤多苷0.5mg/(kg·d)治疗,对照组应用免疫抑制剂。观察三组患者治疗后24h尿蛋白定量、尿素氮、肌酐、环孢素用量及副作用。结果常规组、半量组均能明显减少蛋白尿,24h蛋白定量均低于对照组(P<0.05)。常规组、半量组患者环孢素用量低于对照组(P<0.05)。半量组副作用低于常规组。结论雷公藤多苷能明显减少肾移植术后出现蛋白尿患者的蛋白尿,达到保护移植肾肾功能及减少环孢素用量。长期应用半量雷公藤多苷能达到常规雷公藤多苷相同治疗效果,副作用轻。
Objective To study the effect of multiglycosides of Tripterygium wilfordii （MTW） for treatment of proteinuria in kidney transplant recipients. Methods Forty-five kidney transplant recipients with proternuria were randomized into 3 groups （n=15） and received full daily dose （1 mg/kg） MTW, half dose （0.5 mg/kg） MTW or no MTW （control） in addition to immunosuppressant therapy. The 24-hour urinary protein （24 h Upro）, blood urea nitrogen （BUN）, serum creatinine （Scr）, dose of ciclosporin and the adverse effects of MTW were recorded. Results MTW at both the full dose and half dose significantly reduced the 24 h Upro as compared to exclusive immunosuppressant therapy （P〈0.05）. The therapeutic dose of ciclosporin in patients with full and half dose of MTW was significantly lower than that in the control group （P〈0.05）, and the patients receiving full dose MTW showed greater adverse effects than those having half dose MTW （P〈0.05）. Conclusions MTW can significantly ameliorate protcinuria, reduce the therapeutic dose of ciclosporin and protect the renal function in kidney transplant recipients. While producing similar therapeutic effect to routine full dose, long-term use of half dose MTW may reduce the adverse effect associated with MTW.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第12期2269-2271,共3页
Journal of Southern Medical University
关键词
肾移植
不同剂量
雷公藤多苷
蛋白尿
kidney transplant
multiglycosides, Tripterygium wilfordii
proteinuria, various doses
