摘要
目的探讨两种不同剂量的来曲唑(LE)对多囊卵巢综合征(PCOS)不孕症妇女的促排卵效果。方法76例拟行宫腔内人工授精(IUI),或指导性生活的无排卵的PCOS不孕症妇女,分为2组,于月经周期第3～7天,每日口服来曲唑2.5mg(1组,36例),或来曲唑5.0mg(2组,40例),停药3d(周期第10天)监测卵泡发育。当优势卵泡最大径线≥14mm时,用尿LH板监测,当出现LH峰时,静脉抽血查卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)和睾酮(T),肌注HCG10000U诱发排卵。比较两组患者的多种临床指标。结果2组的排卵率、刺激卵泡的天数、优势卵泡的最大径线及子宫内膜厚度与1组无差异(P>0.05),但其优势卵泡的个数及妊娠率显著高于1组(P<0.05),两组第3天及LH峰日的生殖激素水平无差异(P>0.05)。结论2组优势卵泡的个数及妊娠率显著高于1组(P<0.05)。
Objective To investigate the effect of two different doses of letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome （PCOS）. Methods Seventy-six PCOS infertile women undergoing intrauterine insemination （IUI） or with anovulation were divided into two groups and received oral letrozole at the daily dose of 2.5 （n=36） or 5.0 mg （n=40） from the 3rd to the 7th day of the menstrual cycle. Three days after discontinuation of the medication （the 10th day of the menstrual cycle ）, ultrasound scanning was performed to monitor the follicle development. When the diameter of the biggest follicle reached 14 mm, the presence of luteinizing hormone （LH） was monitored; when LH positivity was detected, blood samples were drawn to test follicle-stimulating hormone （FSH）, Lid, estradiol （E2） and testosterone （T） levels. Human chorionic gonadotropin （hCG, 10 000 U） was then injected to induce ovulation. Results The ovulation rate, stimulation follicle days, diameter of the biggest follicle on the day of LH positivity and the thickness of endometrium were all similar between the two groups （P〉0.05）. But in women receiving 5.0 mg letrozole, both the number of mature follicles and pregnancy rate were significantly higher than those in women having the half dose （P〈0.05）. The levels of FSH, LH, E2, and T on the third day of menstruation and on the day of HCG injection were similar between the two groups （P〉0.05）. Conclusion Letrozole at the dose of 5.0 mg/day produces higher pregnancy rate and more mature follicles in fertile women with PCOS.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第11期2060-2062,共3页
Journal of Southern Medical University
