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247例社区获得性肺炎的病原学分析 被引量：9

Etiological analysis of 247 cases community-acquired pneumonia
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摘要 目的:分析第二军医大学长征医院社区获得性肺炎(CAP)的病原学分布及常见细菌的耐药性,为CAP的经验治疗提供依据。方法:收集2003年9月至2006年12月间我院收治的247例社区获得性肺炎患者,采集痰、支气管吸出物和血标本,进行细菌学和非典型病原体的检测。结果:247例患者中,共有128例患者病原学检测阳性,混合感染20例(15.6%)。居前3位的病原体分别为肺炎支原体39例(26.4%),流感嗜血杆菌23例(15.5%),肺炎链球菌17例(11.5%),肺炎衣原体17例(11.5%)。同时应用PCR和血清学两种方法对标本进行非典型病原体的检测,肺炎支原体、肺炎衣原体和嗜肺军团菌的诊断符合率分别为84.6%(33/39)、23.5%(4/17)和14.3%(1/7)。就诊前有无使用抗菌药物对于苛养菌检出率的影响显著。结论:流感嗜血杆菌和肺炎链球菌仍是CAP最常见的致病细菌,但非典型病原体尤其是肺炎支原体感染在CAP中已占据重要地位。应用血清学检测方法联合PCR方法或尿抗原检测,可以增加非典型病原体检测的敏感性和特异性。
作者 黄海 修清玉 方正 颜泽敏
机构地区 第二军医大学长征医院呼吸内科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2008年第12期1511-1514,共4页 Academic Journal of Second Military Medical University
关键词 社区获得性肺炎 病原学 临床分析
分类号 R563.1 [医药卫生—呼吸系统]
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参考文献16

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二级参考文献12

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共引文献1099

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引证文献9

二级引证文献47

第二军医大学学报
2008年 第12期

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