摘要
目的:提高对自身免疫性肝炎(AIH)的认识,减少漏诊和误诊。方法:回顾性分析26例确诊为AIH患者的临床特征。结果:AIH多见于女性,平均发病年龄(42.3±11.1)岁,84.61%的患者表现为隐匿性或慢性起病过程,有19.23%的患者急性起病,74.3%的患者以胃肠道就诊。所有患者均有血清中转氨酶和谷氨酰转肽酶升高,胆红素升高占76.92%,球蛋白升高占80.76%;自身免疫性肝炎相关抗体阳性占83.25%。结论:AIH女性多发,临床表现缺乏特异性,易漏诊和误诊,对于有肝功能损害、肝炎病毒标记物阴性、球蛋白升高的患者应及时行自身抗体和肝脏组织学的检查,早期诊断及治疗可改善预后。
Objective To enhance the understanding of the clinical features, diagnosis, treatment and prognosis of autoimmune hepatitis （AIH） and decrease AIH misdiagnosis. Methods twenty- six cases of AIH in Ma＇anshan Hospital of Infectious Diseases and Rijin hospital were analyzed retrospectively. Results The majority of patients were women and the average age was （42.3±11.1） years. Thirty-two patients （84.61%） had insidous or chronic onset while five patients （19. 23%） had acute onset. Nineteen patients （74. 3%） showed unspecific manifestations of gastrointestinal tract, which made them go to to see a doctor. All of the patients had higher levels of aspartate aminotransferas （AST） and alanine aminotransferase （ALT）. Twenty patients （76.92 % ） had higher level of hilirubin, and twenty--one （80. 76%） had higher level of immunoglohulin. Twenty--two patients （83.25%） were positive for AIH--related antibodies. Conclusion AIH is usually misdiagnosed and its manifestations have no specificity. Early diagnosis and treatment will improve prognosis.
出处
《中国农村卫生事业管理》
2008年第12期956-958,共3页
Chinese Rural Health Service Administration
关键词
自身免疫性肝炎
临床表现
诊断
autoimmune hepatitis
clinical manifestation
diagnosis
treatment
