摘要
目的:观察血清维生素B12(VitB12)的水平与急性白血病不同类型、不同疾病阶段的关联。方法:收集140例确诊为急性白血病的患者,其中急性髓系白血病(acute myeloid leukemia,AML)95例、急性杂合型白血病(hybrid acute leukemia,HAL)2例、急性淋巴细胞性白血病(acute lymphoblastic leukemia,ALL)43例,分成3组:初治组63例、第1次完全缓解(complete response,CR)组(CR1组)57例以及复发组20例。应用化学发光法检测3组患者血清VitB12的水平。结果:初治组中,血清VitB12水平的升高主要见于AML患者,尤其是M3患者。AML初治患者中血清VitB12水平升高者显著多于CR1的AML患者(P<0.01);AML复发患者中血清VitB12水平升高者也显著多于CR1组的AML患者(P<0.01)。ALL初治患者与CR1患者相比,血清VitB12水平的差异无统计学意义(P>0.05);但ALL复发患者的血清VitB12水平升高者显著多于CR1的ALL患者(P<0.01)。结论:VitB12是急性白血病的诊断指标之一,在急性白血病患者中存在血清VitB12水平的动态变化,血清VitB12水平的升高与疾病活动程度相关。
Objective：To observe the association of serum level of vitaminB12 with various kinds and different development status of acute leukemia （AL）. Methods： One hundred and forty AL patients included 95 acute myeloid leukemia （AML） patients, 2 hybrid acute leukemia （HAL） patients, and 43 acute lymphoblastic leukemia （ALL） patients. They were divided into three groups： first diagnosed group （n = 63） who were first diagnosed as AL without chemotherapy; first complete response （CR1） group （n = 57） who were at first complete remission phase; relapsed group （n = 20） who were at relapsed phase. Serum vitaminB12 level was tested in these patients with chemiluminescence analysis. Results： Increased serum vitaminB12 level was mainly observed in AML patients especially in M3 patients. The number of patients with increased serum vitaminB12 level in first diagnosed group and relapsed group was more than that in CR1 group in AML patients （ both P 〈0.01 ）. Serum vitaminB12 level had no significant difference between first diagnosed group and CR1 group in ALL patients （P 〉0.05）. But the serum vitaminB12 level increased in relapsed group than that in CR1 group （P 〈 0.01 ）. Conclusion： VitaminB12 is one of the markers for AL. There exist dynamic variations of serum VitB12 level in AL patients. Elevation of serum vitaminB12 level is related with the active degree of the disease.
出处
《肿瘤》
CAS
CSCD
北大核心
2008年第12期1074-1076,共3页
Tumor
基金
2007年常州市第二十批科技计划项目(编号:CS2007910)
