摘要
用新建立的血清直接测定法测定８０例正常人，７８例原发性肝癌病人，８４例肝炎、肝硬化病人以及２２例转移性肝癌病人血清的异常凝血酶原含量，取其正常参考值高限为９．４０ＩＵ／ｍｌ，原发性肝癌的阳性率为６１．５４％，肝炎、肝硬化的阳性率为２３．８１％，转移性肝癌的阳性率为１３．６４％，原发性肝癌的阳性率显著高于其他两组（Ｐ＜０．００１），证明血清异常凝血酶原含量可作为原发性肝癌诊断的一项指标。将异常凝血酶原与ＡＦＰ两项指标平行联合检测，使原发性肝癌的阳性率由单项检测的６１．５４％和６７．９５％提高到８４．６２％，两项指标串联联合测定，则对原发性肝癌诊断的特异性，由单项检测的７６．１９％和８４．５２％提高至９７．６２％。
We developed a new method to assay abnormal prothrombin in 80 healthy persons, 78 patients with primary liver cancer (PLC), 84 patients with cirrhosis and chronic hepatitis, and 22 patients with metastatic liver cancer. 9.40 IU/ml was supposed as the highest limit of normal prothrombin level.The positive rates of abnormal prothrombin in PLC,cirrhosis and chronic hepatitis, and metastatic liver cancer were 61.54%, 23.81% and 13.64% respectively.The positive rate in PLC was remarkably higher than the other groups (P<0.001).Combination of abnormal prothrombin with AFP assay significantly elevated the positivity than determining either one alone in the diagnosis of primary liver cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第2期90-92,共3页
Chinese Journal of Clinical Oncology
基金
广州医学院青年科研基金
关键词
异常凝血酶原
血清直接测定法
甲胎蛋白
肝肿瘤
Desycarboxyprothrombin Diagnosis AlphafetoproteinPrimary liver carcinoma
