摘要
AIM： TO determine the expression of DNA （MMR） proteins, including hMLH1 and hMSH2, in gastric epithelial cells in the patients with or without Helicobacter pylori （H pylori）-infected gastritis. METHODS： Fifty Hpylori-positive patients and 50 H pylori-negative patients were enrolled in the study. During endoscopy of patients with non-ulcer dyspepsia, two antral and two corpus biopsies were taken for histological examination （Giemsa stain） and for immunohistochemical staining of hMLH1 and hMSH2. RESULTS： The percentage of epithelial cell nuclei that demonstrated positivity for hMLH1 staining was 84.14 ± 7.32% in Hpylori-negative patients, while it was 73.34 ±10.10% in Hpylori-positive patients （P 〈 0.0001）. No significant difference was seen between the two groups regarding the percentage of epithelial cell nuclei that demonstrated positivity for hMSH2 staining （81.16±8.32% in H pylori-negative versus 78.24 ± 8.71% in Hpylori-positive patients; P = 0.09）. CONCLUSION： This study indicates that Hpylori might promote development of gastric carcinoma at least in part through its ability to affect the DNA MMR system
瞄准：为了决定 DNA (MMR ) 蛋白质的表示，包括 hMLH1 和 hMSH2，在在病人与或没有 Helicobacter 的胃的上皮细胞， pylori (H pylori ) 感染了胃炎。方法：五十个 H pylori 积极的病人和 50 H pylori 否定的病人在学习被注册。在有非溃疡消化不良的病人的内视镜检查法期间，二窦和二语料库活体检视为组织学的检查(Giemsa 污点) 并且为免疫被拿 hMLH1 和 hMSH2 的组织化学的染色。结果：为染色的 hMLH1 表明了确实的上皮的房间原子核的百分比是 84.14 +/-7.32% 在 H pylori 否定的病人，当它是 73.34 +/- 时 10.10% 在 H pylori 积极的病人(P < 0.0001 ) 。没有有效差量关于为染色的 hMSH2 表明了确实的上皮的房间原子核的百分比在二个组之间被看见(81.16 +/-8.32% 在 pylori 否定的 H 对 78.24 +/-8.71% 在 H pylori 积极的病人；P = 0.09 ) 。结论：这研究显示 H pylori 可能通过它影响 DNA MMR 系统的能力部分地至少支持胃的癌的开发。
