摘要
AIM： To explore the influence of portal vein hemodynamic changes after portal venous arterialization （PVA） on peribiliary vascular plexus （PVP） morphological structure and hepatic pathology, and to establish a theoretical basis for the clinical application of PVA. METHODS： Sprague-Dawley rats were randomly divided into control and PVA groups. After PVA, hemodynamic changes of the portal vein and morphological structure of hepatohilar PVP were observed using Doppler ultrasound, liver function tests, ink perfusion transparency management and three-dimensional reconstruction of computer microvisualization, and pathological examination was performed on tissue from the bile duct wall and the liver. RESULTS： After PVA, the cross-sectional area and blood flow of the portal vein were increased, and the increase became more significant over time, in a certain range. If the measure to limit the flow in PVA was not adopted, the high blood flow would lead to dilatation of intrahepatic portal vein and its branches, increase in collagen and fiber degeneration in tunica intima. Except glutamic pyruvic transaminase （GPT）, other liver function tests were normal. CONCLUSION： Blood with a certain flow and oxygen content is important for filling the PVP and meeting the oxygen requirement of the bile duct wall. After PVA, It is the anatomic basis to maintain normal morphology of hepatohilar bile duct wall that the blood with high oxygen content and high flow in arterialized portal vein may fill PVP by collateral vessel reflux. A adequate measure to limit blood flow is necessary in PVA.
瞄准：探索门静脉的影响，并且为 PVA 的临床的申请建立一个理论基础在门以后的血液动力学的变化仙子上的静脉的动脉血化(PVA ) 胆汁的脉管的丛(PVP ) 词法结构和肝的病理。方法：Sprague-Dawley 老鼠随机被划分成控制和 PVA 组。在 PVA 以后，门静脉的血液动力学的变化和 hepatohilar PVP 的词法结构用 Doppler 超声，肝功能测试，墨水灌注透明性管理和计算机的三维的重建被观察微可视化，和病理学的检查从胆汁管墙和肝在织物上被执行。结果：在 PVA 以后，门静脉的代表性的区域和血流被增加，并且增加随着时间的过去变得更重要，在某个范围。如果在 PVA 限制流动的措施没被采用，高血流将导致肝内门静脉和它的分支的膨胀，在大桶集成通信适配器内膜在骨胶原和纤维退化增加。除了 glutamic 焦葡萄酸转氨酶(通用终端) ，另外的肝功能测试是正常的。结论：有某个流动和氧含量的血为充满 PVP 并且遇见胆汁管墙的需氧量是重要的。在 PVA 以后，维持有在 arterialized 门静脉的高氧含量和高流动的血可以由并行管倒流充满 PVP 的 hepatohilar 胆汁管墙的正常形态学是解剖基础。限制血流的一项足够的措施在 PVA 是必要的。
基金
Supported by Science and Technology Plan of Xiamen City,No.3502Z20064005
Health Bureau of Xiamen City,No.WSk0521
