摘要
The disposition of most drugs is highly dependent on specialized transporters. OAT1 and OAT3 are two organic anion transporters expressed in the basolateral membrane of renal proximal tubule cells, identified as contributors to xenobiotic and endogenous organic anion secretion. It is well known that cholestasis may cause renal damage. Impairment of kidney function produces modifications in the renal elimination of drugs. Recent studies have demonstrated that the renal abundance of OAT1 and OAT3 plays an important role in the renal elimination of organic anions in the presence of extrahepatic cholestasis. Time elapsed after obstructive cholestasis has an important impact on the regulation of both types of organic anion transporters. The renal expression of OAT1 and OAT3 should be taken into account in order to improve pharmacotherapeutic efficacy and to prevent drug toxicity during the onset of this hepatic disease.
大多数药的布置高度依赖于专业化运输 ers。OAT1 和 OAT3 是在肾的近似小管房间的 basolateral 膜表示的二器官的阴离子运输 ers，作为贡献者识别了到 xenobiotic 和内长的器官的阴离子分泌物。胆汁郁积可以引起肾的损坏，是众所周知的。肾功能的缺陷在药的肾的消除生产修正。最近的研究证明了肾的许多 OAT1 和 OAT3 面对额外的肝的胆汁郁积在器官的阴离子的肾的消除起一个重要作用。在妨碍的胆汁郁积在器官的阴离子运输 ers 的两种类型的规定上有重要影响以后，时间过去了。OAT1 和 OAT3 的肾的表示应该被考虑以便改进 pharmacotherapeutic 功效并且在这肝的疾病的发作期间阻止药毒性。
基金
Supported by Grants from FONCyT (PICT 05-20201) and CONICET (PIP 5592)
