摘要
目的了解白血病患者表达炎症因子IL-6、IL-8、IL-10与VEGF的水平与意义。方法以ELISA方法观察30例正常人和47例白血病患者血清IL-6、IL-8、IL-10、VEGF水平。结果初治患者血清IL-6、IL-8、IL-10、VEGF水平均明显高于对照组(P<0.05)。部分缓解组IL-6、IL-8、IL-10、VEGF较治疗前明显降低(P<0.05),但仍高于对照组。完全缓解时渐趋正常。结论炎症因子与VEGF在白血病不同病期变化,除了肿瘤性病因所致,也与肿瘤性血管内皮损伤有关,导致肿瘤性易栓状态。这些因子可作为观察白血病患者合并高凝状态观察指标。
Objective The expression and significance of IL-6, IL-8, IL-10, VEGF in acute and chromic leukemia. Methods The serum leveles of IL-6, IL-8, IL-10, VECF in 47 patients with acute and chromic leukemia and 30 normal people were measured by ELISA method. Results Before therapy patients with acute and chromic leukemia had a higher levels of IL-6, IL-8, IL-10, VEGF compared to other groups （P 〈 0.05）. After therapy of acute and chromic leukemia who were partial remission IL- 6, IL- 8, IL- 10, VECF all decreased compared to before therapy（ P 〈 0.05 ） , but they still had higher levels compared to nor- mal control group. There was no evident difference about IL-6, IL-8, IL-10, VEGF between complete remission and normal control group. Conclusion The change of inflammatory factor and VEGF in different stage of acute and chromic leukemia is related with tumor etiopathogenisis and tumor thrombophilia state. These factor can be used as the indicators of leukemia patients complicating thrombophilia state.
出处
《血栓与止血学》
2008年第6期261-263,共3页
Chinese Journal of Thrombosis and Hemostasis
基金
江苏省扬州市社会发展基金项目(编号:YZ2003Z006)
关键词
白血病
炎症因子
Leukemia
Inflammatory Factor
