摘要
目的探讨应用抗结核药物过程中所致药物性肝损害的临床特点、预防和治疗措施。方法根据服抗痨史、临床表现、X线检查、实验室检查及药物性肝损害的诊断标准，对2004-01-2005-01间，收治的446例肺结核患者经抗结核药物治疗后出现的48例药物性肝损害患者进行回顾性分析。结果接受抗结核治疗的446例患者出现的48例药物性肝损害多发生在用药后的1-8周内，且多见于年龄≥60岁的老龄、乙肝病毒标志物阳性、酗酒、营养不良等高危人群，及耐药、耐多药肺结核患者。结论常规检测乙型肝炎病毒感染。对乙肝病毒感染、酗酒、营养不良、耐药、耐多药肺结核的高危险因素人群，需密切观察肝功能情况，做到早发现、早预防、早治疗，有助于帮助患者顺利完成抗结核治疗疗程。
Objective To discuss the clinical characteristics, prevention and treatment of liver injury caused by anti - tuberculosis drug. Methods The clinical materials of 446 cases of such patient were analyzed retrospectively in their history, clinical manifestation, X - ray, lab test and liver injury standard from January 2004 to January 2005. Results There were 48 cases in 446 who had liver injury. There were common in age over 60, hepatitis B positive, alcohol malnutrition and drug resistant patient within 1 - 8 weeks. Conclusion These high risk factor patient should be observe their liver function changes so that to obtain early diagnosis, prevention and treatment.
出处
《黑龙江医学》
2008年第12期924-926,共3页
Heilongjiang Medical Journal
关键词
抗结核药物
高危险因素
药物性肝损害
Antituberculosis drug
High risk factor
Drug-related liver injury
