摘要
目的观察FOLFOX4化疗方案治疗晚期胃肠道肿瘤的疗效和毒性反应。方法36例晚期胃肠道肿瘤患者,其中胃癌16例,结直肠癌20例。给予奥沙利铂(L-OHP)85mg/m2静脉滴注2h,第1天;亚叶酸钙(CF)200mg/m2静脉滴注,2h,第1、2天;氟尿嘧啶(5-FU)400mg/m2,静脉推注,第1、2天,5-FU600mg/m2微泵持续静脉滴注,22h,第1、2天,2周重复,4周为1个周期。2个周期后以WHO评价标准评价疗效和毒性。结果总有效(CR+PR)率为44.6%,其中胃癌总有效率为37.5%,结直肠癌总有效率50%,两组比较差异无统计学意义(P>0.05),中位缓解时间7.4个月,中位生存期11.4个月,1年生存率为50%。主要毒副反应为急性造血系统,感觉神经毒性和胃肠道反应,对症治疗均能耐受。结论FOLFOX4方案治疗晚期胃肠道肿瘤有提高总生存率的趋势,但远期生存率和后期并发症尚需进一步观察。
Objective To investigate the effect and toxicity on FOLFOX4 chemotherapy regimen for advanced carcinoma of gastrointestinal tract. Methods From May 2004 to May 2006,36 patients were entered into this study, the patients＇ characteristics were： 25 males and 11 females, with median age of 60.4 years （ range 54 - 72） ; Karnofsky performance sore 〉 70 ; the regimen consisted of oxaliplatin （ 85 mg/m2, dl, ivdrip）,calciumfolinate（200 mg/m2 ,d1～2 ,ivdrip） ,and fluorouracil （400 mg/m2 ,d1 ～ 2 iv bolus and 600 mg,/m2 dl 2 civ 22 h）, repeaf per weeks,it is one cycle per 4 weeks, the effect and toxicity as shown by the WHO staging system after two cysles. Results All patients can fulfil the treatment plan. The overall respond（ CR ＋ PR） was 41.6% , among them the gastric carcinoma of 37.5% , colorectal carcinoma of 45% （ P 〉 0.05 ） , the 1-year rate was 50.0%. Chief toxicities were acute hematological toxicities （Such as leukopenia）, sensory nerve and gastrointestinal toxicities but they were tolerable after symptomatic treatment. Conclusion There is tendency to increase the overall survival rate on FOLFOX4 ragimen for advanced carcinoma of gastrointestinal tract, longterm survival and late toxicities need further observation.
出处
《中国实用医药》
2008年第36期48-50,共3页
China Practical Medicine
关键词
晚期胃肠道肿瘤
奥沙利铂
亚叶酸钙
氟尿嘧啶
Advanced carcinoma of gastrointestinal tract
Oxaliplatin
Caleiumfolinate
Fluorouracil
