摘要
探讨窒息缺氧对新生儿免疫功能的影响,为新生儿窒息复苏后易患感染性疾病的机理及治疗提供理论参考.方法 以正常新生儿为对照,检测了窒息新生儿外周血T淋巴细胞亚群、血清可溶性白细胞介素-2受体、免疫球蛋白及补体的变化.结果新生儿窒息后:(1)CD_4^+细胞减少,CD_8^+细胞增加,CD_4/CD_8比值降低(P<0.01、0.0025);而且重度窒息儿CD_3^+细胞亦明显减少(P<O.05).(2)血清可溶性白细胞介素-2受体水平显著升高(P<0.0025).(3)血清IgM和C_3明显降低(P<0.01,0.05).结论窒息缺氧可导致新生儿免疫功能紊乱,并对其发生机理及临床意义进行了讨论.
To explore the influence of perinatal asphyxia on neonatal immunity function, to offer the theortic reference of the mechanism and treatment, of which the infective diseases were easily suffered after neonatal asphyxia. Methods Fifty-five neonates were divided into experimental group and control group, the T lymphocyte sub-population, the levels of serum soluble interleukin-2 receptor (SIL-2R), the serum im-munioglobin (Ig) and the complement (C3) were determinated respectively. Results In neonatal asphyxia : (1)CD4 cells decreased markedly and CD8 cells increased significantly, CD4/CD8 ratio decreased markedly ( P < 0. 01,0. 025). Forthemore, CD3 cells decreased significantly in severe asphyxic infants( P <0. 05). (2)the levels of serum SIL-2R increased markedly ( P < 0.0025). (3) the levels of serum IgM and C3 decreased markedly( P <0. 01, 0. 05).Conclusions Asphyxia would lead immunity function disorders in neonates.
关键词
新生儿窒息
免疫学
复苏
处理
Neonatal asphyxia Variation in immunology
