1Park H, Li Z, Yang XO, et al. A distinct Lineage of CD4^+ T cells regualate tissue inflammation by producing interleukin 17 [ J ]. Nat Immunol, 2005,6 ( 11 ) : 1133 - 1141.
2Harrington LE,Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4^+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineage [ J ]. Nat Immunol, 2005,6 ( 11 ) : 1123 - 1132.
3Cua DJ,Sherlock J, Chen Y, et al. Interleukin-23 rather than Interleukin-12 is the critical cytokine for autoimmune inflammation of the brain[ J]. Nature, 2003,421 (6924) :744 - 748.
4Weaver CT,Harrington LE, Mangan PR, et al. TH17: an effecter CD4^+ T cell lineage with regulatory T cell ties [ J ]. Immunity, 2006,24 ( 6 ) : 677 - 688.
5Annunziato F,Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human TH17 cell [ J]. J Exp Med, 2007,204 ( 8 ) : 1849 - 1861.
6Ivanov Ⅱ, Mckenzie BS, Zhou L, et al. The orphan nuclear receptor RORγt directs the differentiation program of pro-inflammatory IL-17^+ T helper cells [ J ] . Cell, 2006,126(6) : 1121 - 1133.
7Zheng Y,Danilenko, DM, Valdez P, et al. Interleukin- 22, a T(H) 17 cytokine, Mediates IL-23-induced dermal inflammation and aeanthosis [ J ]. Nature, 2007,445 (7128) :648 -651.
8Nurieva R,Yang XO, Martinez G, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells [ J ]. Nature, 2007, 448 ( 7152 ) : 480 - 483.
9Langrish CL,Chen Y, Blumenschein WM, et al. IL-23 drives a pathegenic T cell population that induces autoimmune inflammation [ J ]. J EXP Med, 2005, 201 (2) :233 -240.
10Gutcher I,Becher B. APC-derived cytokines and T cells polarization in autoimmune inflammation [ J ]. J Clin Invest,2007,117(5) :1119 - 1127.
3Mannon PJ,Fuss IJ,Mayer L,et al.Anti.interleukin-12 antibody for active Crohn's disease[J].N Engl J Med,2004,351(20):2069-2079.
4Hunter C A.New IL-12-family members:IL-23 and IL-27,cytokines with divergent functions[J].Nat Rev Immunol,2005,5(7):521-531.
5Aranami T,Yamamura T.Th17 cells and autoimmune encephalomyelitis (EAE/MS)[J].Allergology International,2008,57(2):115-120.
6Komiyama Y,Nakae S,Matsuki T,et al.IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis[J].Journal of Immunology,2006,177(1):566-573.
7Sato K,Suematsu A,Okamoto K,et al.Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction[J].JEM,2006,203(12):2673-2682.
8Grevers LC,Van Lent PL,Koenders MI,et al.Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis[J].Arthritis Rheum,2009,60(2):396-407.
9Kirkham BM,Lassere MN,Edmonds JP,et al.Synovial membrane cytokine expression is predicitive of joint damage progression in rheumatoid arthritis:A two-year prospective study(the DAMAGE study cohort)[J].Arthritis Rheum,2006,54(4):1122-1131.
10Lubberts E.IL-17/Th17 targeting:On the road to prevent chronic destructive arthritis[J].Cytokine,2008,41(2):84-91.
