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自然反义转录子与人类肿瘤

Natural Antisense Transcripts and Human Tumor
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摘要 自然反义转录子(natural antisense transcripts,NAT)在生物界中广泛存在,且发挥着重要的基因表达调控作用。NAT表达水平的高、低可调控多种生物的多种重要的生理活动,尤为重要的是,目前已经证实aHIF、gfg-1、p15AS、rTSα等NAT分子能直接作用于多种肿瘤相关的关键因子,其异常表达与多种肿瘤的发生、发展有密切关系。 Natural antisense transcripts （NAT） exist extensively in prokaryotic and eukaryotic biological kingdom and exert important function in regulating gene expression. The expression level of NAT may control numerous physiological activities in a variety of organism. Furthermore, it has been confirmed that NATs, such as aHIF, gfg-1, plSAS and rTSα, are expressed abnormally in various types of tumor during tumorigenic development and progression. The targets of those NAT are key tumor related factors. Therefore, elucidation of the function and mechanism of NATs is of great importance.
作者 杨朝辉 何凤田
机构地区 第三军医大学生物化学与分子生物学教研室
出处 《医学分子生物学杂志》 CAS CSCD 2008年第6期539-541,共3页 Journal of Medical Molecular Biology
关键词 自然反义转录子 低氧诱导因子 胸苷酸合成酶 成纤维细胞生长因子 肿瘤 natural antisense transcripts hypoxia induced factors thymidylate synthetase fibroblast growth factor tumor
分类号 Q785 [生物学—分子生物学]
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参考文献14

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医学分子生物学杂志
2008年 第6期

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