摘要
以正常人和脐带血人单核细胞作为登革Ⅱ型病毒（Ｄ２Ｖ）感染的靶细胞，研究了肿瘤坏死因子α（ＴＮＦα）对Ｄ２Ｖ复制的影响以及人单核细胞感染Ｄ２Ｖ后ＴＮＦα产生能力的变化，动态观察了６６例登革感染病人不同发病天数血清中ＴＮＦα水平．结果表明ＴＮＦα能增加Ｄ２Ｖ的复制（Ｐ＜０．０５），高剂量Ｄ２Ｖ（１００ｐｆｕ／ｃｅｌ）感染能引起人单核细胞产生ＴＮＦα，病人血清中ＴＮＦα水平明显升高（Ｐ＜０．０５）．结果提示ＴＮＦα促进登革病毒感染．
Human monocytes from normal peripheral blood and cord blood were used as dengue-2 virus(D2V) infected target cells.The effect of TNFα on D2V replication and production of TNFα by D2V infected monocytes were studied,level of TNFα in sera of dengue patients was also studied.The results showed that TNFα could enhance D2V replication in human monocytes,Level of TNFα produced by human monocytes infected with high concentration of D2V and level of TNFα in sera of dengue patients was increased.The results suggested that TNFα enhances dengue virus infection.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1997年第5期112-115,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
