摘要
目的探讨青春期卵巢生殖细胞肿瘤的临床表现、病理特点、治疗及预后。方法回顾性分析1995年1月至2005年12月安徽省立医院和安徽友谊医院收治的59例青春期卵巢生殖细胞肿瘤患者的临床资料。结果本组患者发病平均年龄16.1岁。所有患者均行手术治疗。经手术病理确诊,成熟性畸胎瘤46例,未成熟性畸胎瘤7例,无性细胞瘤2例,内胚窦瘤3例,混合型生殖细胞肿瘤1例。恶性肿瘤以Ⅰ期最多,其中Ⅰa期10例,Ⅰc期2例,Ⅲc期1例。治疗首选保守性手术。其中卵巢肿瘤剔除术38例;患侧附件切除术8例;患侧附件切除术及分期手术9例;患侧附件、大网膜切除术及分期手术3例;全子宫、双附件、大网膜切除术及盆腔淋巴结清扫术1例。恶性肿瘤术后行PVB或BEP方案化疗3-6个疗程。所有良性肿瘤术后随访无复发。13例恶性肿瘤患者2例已死亡,11例随访无复发。结论青春期卵巢生殖细胞肿瘤临床表现多为非特异性;病理类型以良性为多,占78%。恶性生殖细胞肿瘤多表现为期别早。青春期卵巢生殖细胞肿瘤无论良恶性以及临床期别的早晚,应尽量行保留生育功能的保守性手术.恶性肿瘤术后采用BEP方案化疗且预后较好。
Aim To study clinical pathology feature and treatment principle of ovarian germ cell tumor in puberty. Methods A retrospective analysis was performed on 59 cases of ovarian germ cell tumor in puberty during the period of 1995 to 2005 in Anhui Provincial Hospital and Anhui Friendship Hospital. Results The average age was 16.1 years old. All cases underwent surgical treatment and had a pathological definite diagnosis, 46 mature teratomas, 7 immature teratomas, 2 dysgerminomas, 3 endodermal sinus tumor, and 1 mixed germ cell tumor. Among malignant tumors, 10 were at stage Ⅰ a,2 stage Ⅰ e and 1 stage Ⅲ c. Ovarian-sparing tumoreetomy was performed on 38 cases, unilateral ecphyadectomy 8 cases, unilateral ecphyadeetomy and staging operation 9 cases, unilateral ecphyadectomy, omentectomy and staging operation 3 cases, radical surgery 1 case. Adjuvant chemotherapy was given to all patients with malignant tumors. All of the benign tumors were without evidence of disease recurrence during the follow-up. Two patients, with malignant disease, died. The others were without evidence of disease recurrence during the follow-up. Conclusion Ovarian germ cell tumors in puberty were mainly benign, with a rate of 78%. Malignant germ cell tumors were mostly at early stage. Operative strategy was conservative surgery of fertility preservation, and adjuvant chemotherapy was performed, which had good prognosis.
出处
《安徽医药》
CAS
2008年第12期1184-1185,共2页
Anhui Medical and Pharmaceutical Journal
