摘要
动态观察１６例心内直视手术患者（川芎嗪保护组８例，非保护组８例）主动脉阻断前、阻断后３０ｍｉｎ及开放后３０ｍｉｎ血乳酸脱氢酶（ＬＤＨ）、超氧化物歧化酶（ＳＯＤ）的活性及丙二醛（ＭＤＡ）含量的变化。结果显示川芎嗪保护组上述指标变化明显较非保护组轻，其差异有显著性或非常显著性意义（Ｐ＜０．０５和Ｐ＜０．０１）。表明川芎嗪对体外循环下心肌缺血再灌注损伤有良好的保护作用。
The serum lactic dehydrogenase(LDH)superoxide dismutase activities and the amount of malondialdehyde(MDA) were dynamically observed before the occlusion of aorta,after 30 minutes of occlusion and after 30 minutes of release respectively, of intracardiac operation under direct vision with the method of extracorporeal circulation(ECC).These patients scheduled for the selective cardial surgery,were randomly divided into two groups: group protected with liqustrazin(n=8) and non protected group(n=8).The results showed that the changes of LDH,SOD and MDA in group protected with liqustrazin were not remarkable than that in non protected group, their difference between the liqustrazin and the non liqustrazin protected group.being significant or very significant.It indicated that liqustrazin had evidently protective effect on the myocardial ischemia reperfusion injury in patients undergoing ECC.
出处
《温州医学院学报》
CAS
1997年第1期13-15,共3页
Journal of Wenzhou Medical College
基金
浙江省教委科研基金
关键词
体外循环
心肌缺血
再灌注损伤
川芎嗪
extracorporeal circulation(ECC)
myocardium
ischemia reperfusion injury
liqustrazin
