摘要
经高压液相色谱分离,萤光光谱法鉴定,狗肌肉注射芘后尿中的代谢产物为1-羟基芘。分别给狗1、2、5μmol/kg芘后,尿中排出的1-羟基芘均以第24-48h期间最高;尿中排出的1-羟基芘约占注入芘的0.05％左右。
With High Performance Liquid Chromatograph and fluorospectrometry, 1-hydroxypyrene is identified as a major metabolite of pyrcne in the dog urine after intra-musculary injection of pyrene. As three successive doses of 1, 2 and 5 μmol/kg. wt pyrene were injected into the dogs, 1-hydroxypyrcne in urinary excretion reached to peak levels within 24-48 hours. The amounts of excreted 1-hydroxypyrene were accounted for about 0.0 5% of the injected pyrene.
出处
《环境科学》
EI
CAS
CSSCI
CSCD
北大核心
1990年第6期14-17,共4页
Environmental Science
基金
国家自然科学基金
关键词
狗
尿
1-羟基芘
排出规律
identification of 1-hydroxypyrene, pyrene, dog urine.
