摘要
目的比较两种胰岛素强化治疗的方法对初诊的糖尿病胰岛β细胞功能的影响。方法42例住院的初诊糖尿病患者,随机分为胰岛素泵持续皮下胰岛素输注组(CSII组,20例)和多次皮下胰岛素注射组(MSII,22例),分别观察两组血糖达标时间、每日胰岛素量、低血糖的发生率及出院后随访糖化血红蛋白(HbA1C)及治疗。结果治疗2周后,两组血糖均良好控制,CSII组所需治疗时间、胰岛素量、低血糖发生率均较MSII组少(P<0.05),平均随访1年,CSII组和MSII组HbA1C分别为(6.22±0.54)%、(6.63±0.95)%,两组各有2人(2/12)和2人(2/15)半年内仅采用饮食控制和运动。结论短期胰岛素强化治疗可使胰岛β细胞功能改善,胰岛素抵抗得到缓解,从而使血糖良好控制;胰岛素泵为糖尿病的强化治疗提供了一种有效的、安全的、方便灵活的治疗手段。
Objective To investigate the efficiency of short-term intensive insulin treatment in 42 newly diagnosed type 2 diabetic patients. Methods 42 type 2 diabetic patients who diagnosed newly were randomly divided into two groups, treated with continuous subcutaneous insulin infusion（CSII 20 cases） and multiple subcutaneous insulin injection（MSII 22 cases） respectively for 2 weeks, the average days of the stable target blood glucose level, daily insulin doses, rate of hypoglycemia were assessed. Thereafter glycated hemoglobin levels and therapies were monitored for 1 year. Results When 2 groups reached the stable target, the average days of treatment, daily insulin doses,rates of hypo- glycemia were markedly decreased in CSII group compared with MSII group. After 1 year of fellow-up, glycated hemoglobin levels of（6.22 ± 0.54）% and（6.63 ± 0.95）% were achieved in CSII group and MSII group, respectively. At the same time, nothing more than diet and exercise were introduced almost in one half an year in two patients between groups. Conclusion Short-term intensive insulin treatment can effectively induce good glycemia control by improving the β -cell function as well as decreasing the insulin resistance in newly diagnosed type 2 diabetic patients, insulin pulp provided the possibility with its utility, safety and convenience.
出处
《中国现代医生》
2008年第33期32-33,共2页
China Modern Doctor
关键词
2型糖尿病
胰岛素强化治疗
Β细胞功能
Type 2 diabetes mellitus
transient intensive insulin treatment
β-cell function
