摘要
目的观察Smac和Ki67在甲状腺癌中的表达,并探讨Smac表达与Ki67的关系及其临床意义。方法应用免疫组织化学法检测87例甲状腺癌组织中Smac和Ki67的表达,分析Smac表达与临床病理因素和Ki67的关系。结果Smac在甲状腺癌组织中的阳性表达率为71.3%(62/87),在所有的腺瘤旁组织中均见表达(20/20);Ki67增殖指数为42.74±14.52。Smac在男性、年龄≥45岁、髓样癌和未分化癌、原发病灶超出包膜、以及Ⅱ、Ⅲ、Ⅳ期甲状腺癌患者中的表达明显降低(P<0.05)。Smac阳性表达患者的Ki67增殖指数较Smac阴性表达者低[(40.70±14.68)vs(47.78±13.06),P<0.05]。结论Smac和Ki67在甲状腺癌中的表达发生改变具有相关性,提示其可能在甲状腺癌的发生发展中发挥重要作用且两者可能具协同作用。
Objective To investigate the expression of Smac and Ki67 in thyroid carcinoma and the correlation of Smac and Ki67, the clinical significance as well. Methods Immunohistochemical staining of Smac and Ki67 expression was performed by the standard streptavidin-peroxidase（SP） technique for the paraffin sections of 87 thyroid carcinoma. The relationship between the Smac expression and the clincopatho-logical parameters or Ki67 proliferation index was analyzed. Results The positive rate of Smac in thyroid carcinoma was 71.3% （62/87）,all of the normal thyroid tissues expressed Smac（20/20）. Ki67 proliferation index in thyroid carcinoma was 42. 74±14. 52. Smac expression was significantly lower in patients of male, over 45 years old, medullary and anaplastic thyroid carcinoma, stage Ⅱ, Ⅲ and Ⅳ, and in those with invasions over capsular（P〈0. 05）. The Ki67 proliferation index in negative expression of Smac was significantly higher than that in positive expression of Smac[（40. 70±14. 68） vs （47. 78±13.06）, P〈0. 05]. Conclusion Smac and Ki67 expression in thyroid carcinoma were significantly different from those in normal tissues, and they had significant correlation, which suggest that they may play an important role or even have synergic action in carcinogenesis and development of thyroid carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2008年第11期800-802,共3页
Cancer Research on Prevention and Treatment
关键词
甲状腺癌
SMAC
Ki67增殖指数
凋亡
增殖
Thyroid carcinoma
Smac
Ki67 proliferation index
Apoptosis
Cell proliferation
