摘要
作者为观察肝脏对胰腺的免疫保护作用和胰腺对肝脏的营养保护作用，采用大鼠单独胰腺移植、单独肝脏移植及肝胰联合移植进行研究。结果显示：胰腺联合肝脏移植时，胰腺平均功能存活期（１３．１±１．０１天）较单独移植（９．２±１．１４天）时显著延长（Ｐ＜０．０５，ｔ检验），间质排斥反应减轻，分级分布与单独移植相比差异有显著意义（Ｐ＜０．０５，）；肝脏在联合移植时，术后再生能力以及形态的完整性优于单独移植。作者认为肝脏和胰腺联合移植时，肝脏能够得到胰腺提供的营养保护作用，胰腺也能得到肝脏的免疫保护作用。
We study observed the mutual benefits of pancreas and liver in combined hepaticopancreatic transplantation in rats. The result indicated that pancreas, when transplanted with liver, could survive for a significantly longer time(134±101 days) than it transplanted alone(92±114 days) (P<005). The interstitial rejection was mild and its rejection grade was significantly different from that of pancreas transplanted alone(P<005,χ2 test). The liver, when transplanted with pancreas, regenerated with strong competence and contact structure morphologically compared with liver transplanted alone. We concluded that pancreas could be immunologically protected against rejection and liver can be nutritionalized by pancreas in combined pancreas and liver transplantation.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1997年第12期749-752,I111,共5页
Chinese Journal of Surgery
关键词
胰腺移植
肝移植
移植免疫学
Pancreas transplantation Liver transplantation Transplantation immunology
