期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IL-6,IL-8,TGF-β与非小细胞肺癌肺内转移之间的关系 被引量：1

暂未订购
导出
摘要 目的检测非小细胞肺癌组织中IL-6，IL-8，TGF-β的表达情况，探讨其与非小细胞肺癌肺内转移之间的关系，为临床判断预后提供参考。方法选择46例原发性非小细胞肺癌患者手术切除的肺癌组织标本制备组织匀浆，对其组织上清液用ELISA测定IL-6，IL-8，TGF-β的表达情况。结果（1）IL-6，IL-8，TGF-β在46例非小细胞肺癌组织中均有不同程度的表达，其中间值分别为198．127pg/mg、160．988pg/mg,65．433pg/mg.（2）IL-8，TGF-β的表达与非小细胞肺癌肺内转移有关（P=0．047，P=0．001）。结论（1）IL-6，IL-8，TGF-β的表达与非小细胞肺癌组织的生长有关。（2）IL-8，TGF-β参与了非小细胞肺癌肺内转移的过程。
作者 韩浩
机构地区 甘肃省第二人民医院
出处 《卫生职业教育》 2008年第22期127-128,共2页 HEALTH VOCATIONAL EDUCATION
关键词 细胞因子 白细胞介素-6 白细胞介素-8 转化生长因子-Β 非小细胞肺癌 肺内转移
分类号 R197 [医药卫生—卫生事业管理]
  • 相关文献

参考文献17

  • 1The Japan Lung Cancer Society. Classification of Lung Cancer [M]. Tokyo: Kanehara & Co., 2000.
  • 2Yamamura M, Modlin RL, Ohmen JD, et al. Local expression of anti-inflammatory cytokines in cancer[J]. J Clin Invest, 1993,91: 1005-1010.
  • 3Macchiarini P, Fontanini G, Hardin M J, et al. Relation of neuvascularisation to metastasis of non-small cell lung cancer[J]. Lancet, 1992, 340: 145.
  • 4Wang JM,Taraboletti G, Matsu shima K, et al. Induction of hypotactic migration of melanoma cells by neutrophil activating protein/IL-8 [J]. Biochem Biophys Res Commun, 1990,169(1):165.
  • 5孙卫民 王惠琴.细胞因子研究方法学[M].北京:人民卫生出版社,1997.367-384.
  • 6Luca M, Huang S, Gershenwald JE, et al. Expression of interleukin-8 by human melanoma cell up-regulates MMP22 activity and increases tumor growth and metastasis[J]. Am J Pathol, 1997, 151(4):1105-1113.
  • 7Nicolas FJ, Hill CS. Attenuation of the TGF-β-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-β-induced growth arrest[J]. Oncogene, 2003,22 : 3698-3711.
  • 8Paterson IC, Patel V, Sandy JR, et al. Effects of transforming growth factor beta-1 on growth-regulatlon genes in tumor-derived human oral keratinocytes[J]. Br J Cancer, 1995,72:982-987.
  • 9Wieser R. The transforming growth factor-beta signaling pathway in tumorigenesis[J]. Curr Opin Oncol, 2001,13:70-77.
  • 10Mc Cartney, Francis NL. TGF-beta: a balancing act[J]. Int Rev Immunol, 1998,16:553-580.

二级参考文献23

  • 1Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor in human disease[J]. N Engl J Med, 2000, 342(18): 1350-1358.
  • 2Imamura T, et al. Smad6 inhibits signaling by the TGF-β superfamily[J]. Nature, 1997, 389 (6651): 622-626.
  • 3Nakao A, Takase M, Nishihara A, etal. Identifieation of Smad7, a TGF-β-inducible antagonist of TGF-β-signaling [J]. Nature, 1997, 389(6651): 631-635.
  • 4Yoo YD, Choi JY, Lee SJ, et al. TGF-beta-induced cell-cycle arrest through the p21 (WAF1/C1P1)-G1 cyclin/Cdks-p130 pathway in gastric-carcinoma cells[J]. Int J Cancer, 1999, 83(4): 512-517.
  • 5Lavarone A , Massague J. Repression of CDK activitor edc25A and cell-cycle arrest by cytokine TGF-β cells in lacking CDK inhibitor p15[J]. Nature, 1997, 387(6631): 417-422.
  • 6Grady WM., Myeroff LL, Swinler S E, et al. Mutational inactivation of transforming growth factor TGF-β receptor type Ⅱ in microsatellite stable colon cancers[J]. Cancer Res, 1999, 59(2): 320-324.
  • 7Goggins M. , Shekher M, Turnacioglu K, et al. Genetic alterations of the transforming growth factor-(receptor genes in pancteafic and biliary adenocarcinomas[J]. Cancer Res, 1998, 58(23): 5329-5332.
  • 8Kang SH, Bang YJ, Im YH, et al. Transcriptional repression of the transforming growth factor type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer[J]. Oncogene, 1999, 18(51): 7280-7286.
  • 9Kleeff J, Ishiwata T, Maruyana H, et al. The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer[J]. Oncogene, 1999, 18(39): 5363-5372.
  • 10Hu W , Wu W, Nash MA, et al. Anomalies of TGF-beta postreceptor signaling pathway in ovarian cancer cell line[J]. Anticancer Res, 2000, 20(2A): 729-733.

共引文献21

同被引文献17

引证文献1

二级引证文献6

卫生职业教育
2008年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部