摘要
采用SD大鼠慢性肾血管性高血压模型,气-液色谱法测定高血压组(n=8)、对照组(n=9)脑细胞膜游离脂肪酸(Free Fatty Acid,FFA)单组分水平。结果显示高血压组脑细胞膜FFA组份中C20:4、C22:6水平显著高于对照组(P<O.01,P<0.05),C18:0水平显著低于对照组(P<O.05),C16:O、C18:1轻度降低(P>O.05)。提示继发性高血压大鼠存在脑细胞膜FFA代谢障碍。
Using chronic renovascular hypertension model of Sprague-Dewley Rats, we determined that content of brain membrane free fatty acids (FFAs) in normotensive (n = 9) and hypertensive (n = 8) rats with GLC technique. The data showed that C20:4,C22 : 6 levels increased significantly (P<0. 01 ,P<0. 05) ,O18 < 0 decreased obviously (P<0. 05), and C16 :0.018 :1 increased slightly from hypertensive group (,PX). 05) as compared with normotensive group. The findings seem to reflect an abnormal metabolism of brain membrane FFAs in experimental hypertensive rats.
出处
《临床神经科学》
1997年第3期145-147,共3页
Chinese Journal of Clinical Neurosciences
