摘要
目的探讨轻度认知损害(MCI)的相关危险因素。方法对2003-10-2004-10北京大学医学部第三医院289例就诊患者进行神经心理测定,对存在睡眠呼吸暂停的患者进行多导睡眠仪(PSG)检查,确诊阻塞性睡眠呼吸暂停综合征(OSAS)患者171例,MCI患者31例;通过logistic回归分析法分析MCI患者患病的危险因素。结果单因素分析显示,文化程度、吸烟史、饮酒史、腔隙性脑梗死、TIA发作、OSAS史与MCI发生有关。多因素分析显示,文化程度(OR:0.270)、短暂性脑缺血发作(TIA)史(OR:3.462)、吸烟史(OR:2.963)、重度OSAS(OR:1.346)是青中年认知功能损害的主要影响因素。结论文化程度、吸烟史、TIA史、OSAS是青中年认知功能损害的可能影响因素。
Objective To investigate the relativity on risk factors of the mild cognitive impairment（MCI）. Methods Neuropsychological test were adopted among a total of 289 outpatients of the third hospital of Beijing university from October 2003 to October 2004. The patients who bothered with sleep apnea were selected and monitored by multiple-lead night sleep monitoring system. 171 of them were diagnosed obstructive sleep apnea sydrome（OSAS） ,and 31 were diagnosed as MCI. Their histories were analyzed by logistic regression, then the risk factors of MCI were explored. Results A multiple factors logistic regression analysis revealed that education, transient ischemia attach （TIA）, smoking and severe degree of OSAS were associatied with the presence of the MCI,while their odd ratios（OR） were 0.27（95%CI：0. 088-0. 827,P=0. 001）, 3. 462（95%CI： 1.628-7.354,P=0.002）, 2. 963 （95%CI：1.266-6.938, P=0.013） and 1.346（95%CI：1.045-1.734, P 0. 002）, respectively. Conclusions Education,smoking,TIA and OSAS were associatied with the presence of the MCI.
出处
《中国神经免疫学和神经病学杂志》
CAS
2008年第6期417-419,426,共4页
Chinese Journal of Neuroimmunology and Neurology
