摘要
用改良Koizumi's局灶脑缺血模型,对比研究了常温、缺血期亚低温、再灌注期亚低温、缺血期加再灌注期亚低温对局部脑血流、血脑屏障及缺血梗塞灶体积影响。发现缺血期加再灌注期及单纯缺血期亚低温均有改善缺血周边区再灌注后急性高灌注和继发低灌流及核心区持续低灌流、减轻血脑屏障破坏、减少缺血梗塞灶体积的作用,该作用尤以前者为明显。
Using modified Koizumi's focal ischemic model,the effects of intra-ischmia(MHTi) ,in-tra-reperfusion (MHTr ) , intra-ischemia/reperfusion (MHTi + r) hypothermia on cortical blood flow, blood-brain barrier (BBB)and infarct volume were compared. The results showed that the acute postischemic hyperperfusion and delayed hypoperfusion in ischemic perifocal region and sustained hypoperfusion in ischemic core were inhibited in both MHTi + r and MHTi rats. The disruption of BBB and the infarct volume were significantly less in both MHTi + r and MHTi groups, especially in the MHTi+r rats. This study demonstrated that MHTi + r has more substantial protective effect on reducing ischemia/reperfusion injury than MHTi.
出处
《临床神经科学》
1997年第2期63-67,共5页
Chinese Journal of Clinical Neurosciences
关键词
脑缺血
再灌注损伤
亚低温
Focal cerebral ischemia Reperfusion injury Mild hypothermia
