摘要
目的探讨双相情感障碍（BPD）不同临床状态下的认知操作模式。方法采用8个神经心理测验（共17项）对BPD的不同临床状态病人（躁狂相、抑郁相和缓解期）各30例和正常对照34例进行注意力、言语学习和记忆、视觉记忆和执行功能的评定，用多变量方差分析的方法比较各组间认知功能的差异。结果1．急性发作的BPD几乎所有的神经心理学测验成绩均差于正常对照组[躁狂相、抑郁相、缓解期和对照组的WCST完成分类数分别为（1．58±0．90）个、（1．89±1．56）个、（2．44±1．42）个、（4．90±1．73）个；即刻逻辑记忆分别为（10．68±3．92）分、（10．00±3．80）分、（12．11±3．72）分、（15．80±4．21）分]，差异有显著性（P〈0．05或P〈0．01），缓解期BPD在注意力、言语学习和记忆、执行功能上的成绩明显低于正常对照组（P〈0．05或P〈0．01）。结论急性发作的BPD存在广泛的认知功能损害，而且可持续至缓解期。
Objective To explore the patterns of cognitive performance across different clinical states of bipolar disorder（BPD）. Methods 8 neuropsychological tests（ 17 items） which examine attention, verbal learning and memory ,visual memory and executive function were given to 30 depressed BPD ,30 manic BPD ,30 remitted BPD and 34 normal controls. The difference of cognitive functions between the four groups were compared using multivariate analysis of variance （MANOVA）. Results Acute patients with BPD showed dysfunction in almost all neuropsychologieal tests compared with controls [the score of WCST categories of manic BPD,depressed BPD, remitted BPD and normal controls was（ 1.58±0.90）, （ 1.89±1.56）, （2.44±1.42）, （4.90±1.73 ） respectively. The score of immediately logical memory was （ 10. 68±3.92） , （ 10.00±3.80 ）, （ 12.11±3.72 ） , （ 15.80±4.21 ） respectively] （ P〈0.05, P〈0.01）. The remitted patients showed deficits in attention, verbal learning and memory, executive function tasks in relation to controls （P〈0.05, P〈0.01）. Conclusion There were general cognitive deficits in acute patients with BPD,and some of these deficits may persists in remission state.
出处
《中国行为医学科学》
CSCD
2008年第11期1007-1009,共3页
Chinese Journal of Behavioral Medical Science
关键词
双相障碍
认知功能
神经心理测验
Bipolar disorder
Cognitive function
Nueropsychology tests
