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超声靶向破坏微泡介导基因转染的研究进展 被引量：3

The review of ultrasound-targeted microbubbles destruction mediated gene transfer
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摘要 超声靶向破坏微泡（ultrasound—targeted microbubble destruction，UTMD）是一项新兴的介导基因转染的技术，较传统病毒载体介导的基因感染方法具有更为安全及组织靶向性的优势。近十多年来，学者们对UTMD研究不断深入，利用该技术进行体内外基因转染的实验研究取得了一定的成果。
作者 李凡 杜联芳
机构地区 上海交通大学附属第一人民医院超声科
出处 《中华超声影像学杂志》 CSCD 2008年第11期1002-1004,共3页 Chinese Journal of Ultrasonography
基金 国家自然基金项目（30772369）
关键词 病毒载体介导 基因转染 靶向性 微泡 超声 感染方法 实验研究 体内外
分类号 R686 [医药卫生—骨科学]
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参考文献39

  • 1Gambihler S, Delius M,Ellwart JW. Permeabilization of the plasma membrane of L1210 mouse leukemia cells using lithotripter shock waves. J Membr Biol, 1994,141 : 267-275.
  • 2Brayman AA,Coppage ML, Vaidya S, et al. Transient poration and cell surface receptor removal from human lymphocytes in vitro by 1 MHz ultrasound. Ultrasound Med Biol, 1999,25:999-1008.
  • 3Unger EC, Matsunaga TO, McCreery T, et al. Therapeutic applications of microbubbles. Eur J Radiol,2002,42 : 160-168.
  • 4Mehier-Humbert S, Bettinger T, Yan F, et al. Plasma membrane poration induced by ultrasound exposure: implication for drug delivery. J Control Release, 2005,104 : 213-222.
  • 5Lai CY,Wu CH, Chen CC, et al. Quantitative relations of acoustic inertial cavitation with sonoporation and cell viability. Ultrasound Med Biol, 2006,32 : 1931-1941.
  • 6Mehier-Humbert S,Bettinger T,Yan F,et al. Ultrasound-mediated gene delivery: kinetics of plasmid internalization and gene expression. J Control Release, 2005,104 : 203-211.
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  • 8Samuel S, Miller DL, Fowlkes JB. The relationship of acoustic emission and pulse-repetition frequency in the detection of gas body stability and cell death. Ultrasound Med Biol,2006,32:439-447.
  • 9Rahim A, Taylor SL, Bush NL, et al. Physical parameters affecting ultrasound/microbubble-mediated gene delivery efficiency in vitro. Ultrasound Med Biol, 2006,32 : 1269-1279.
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同被引文献15

  • 1田力,李继昌,赵国强,袁建军,陈奎生,蔡庆春.超声辐照携TIMP-1 siRNA微泡对大鼠肝纤维化的影响[J].中国医学影像技术,2007,23(7):960-962. 被引量：2
  • 2Kinoshita M, Hynynen K. A novel method for the intracellular delivery of siRNA using microbubble-enhanced microbcused ultrasound. Biochem Biophys Res Commun, 2005,335 (2) : 393-309.
  • 3Tsunoda S, Mazda O, Oda Y, et al. Sonoporation using microbubble BR14 promotes pDNA/siRNA transduetion to murine heart. Bioehem Biophys Res Commun, 2005,336 (1) : 118-127.
  • 4Otani K, Yamahara K, Ohnishi S, et al. Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles. J Control Release, 2009, 133(2) : 146-153.
  • 5Wang X, Liang HD, Dong B, et al. Gene transfer with microbubble ultrasound and plasmid DNA into skeletal muscle of mice: comparison between commercially available microhubble contrast agents. Radiology, 2005,237 (1) : 224-229.
  • 6Duvshani-Eshet M, Adam D, Maehluf M. The effects of albumin-coated microbubbles in DNA delivery mediated by therapeutic ultrasound. J Control Release, 2006,112(1):156-166.
  • 7Duvshani-Eshet M, Baruch L, Kesselman E, et al. Therapeutic ultrasiund-mediated DNA to cell and nucleus: bioeffects revealed by confocal and atomic force microscopy. Gene Therapy, 2006,13 (2) :163-172.
  • 8伍瑛,杜联芳,顾青,王惠萍,王丰,李凡.声诺维增强超声辐照介导pEGFP-N1转染RPE细胞的实验研究[J].中国超声医学杂志,2007,23(5):321-323. 被引量：4
  • 9任建丽,王志刚,许川山,张勇,李兴升,苏琳,张群霞.超声微泡促进TDL复合物介导基因转染的体外实验[J].中国超声医学杂志,2008,24(5):385-388. 被引量：2
  • 10Stefania Xenariou,Hai-Dong Liang,Uta Griesenbach,Jie Zhu,Raymond Farley,Lucinda Somerton,Charanjit Singh,Peter K. Jeffery,Ronald K. Scheule,Seng H. Cheng,Duncan M. Geddes,Martin Blomley,Eric W. F. W. Alton.Low-frequency ultrasound increases non-viral gene transfer to the mouse lung[J].Acta Biochimica et Biophysica Sinica,2010,42(1):45-51. 被引量：3

引证文献3

二级引证文献4

中华超声影像学杂志
2008年 第11期

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