摘要
应用免疫组化LSAB法对33例原发性子宫内膜腺癌进行p21ras、p53的检测，结果显示子宫内膜腺癌p21ras表达为51．5％，p53表达为78．8％，p21ras和p53在正常子宫内股无表达，说明p21ras和p53在子宫内膜腺癌的表达较特异。本研究显示p53与子宫内膜腺癌的病理分级有关（P＜0．05），p21ras与转移及临床分期有关（P＜0．05）。在子宫内膜腺癌中，p53的表达与p21ras的表达之间呈显著相关（P＜0．01）。另外发现随着肿瘤分化越差p21ras、p53阳性率增加。本研究提示子宫内膜腺癌的发生、发展，与p21ras、p53有关，p21ras、p53可作为诊断子宫内膜腺癌的参考指标。
The expressions of p21ras and p53 were studied in 33 cases of endometral adenocarcinoma by LSAB immunohistochemical technique. The positive expressions of p21ras and p53 were 51. 5 % and 78. 8%, respectively.The positive expressions of p21ras and p53 were not observed in normal endometrium. The results indicate that the expressions of p21ras and p53 are specific, and the p53 expression was correlated with the histological grade (P＜0.05). The p21ras expression was associated with metastasis and clinical stage (P＜0. 05). There was significant correlation between the expression of p53 and that of p21ras (P＜0. 01). On the other hand, it was found that the rates of positive p53 and p21ras expressions were increased with the poor differentiation of endometral adenocarcinoma. The results demonstrate that p53 and p21ras are correlated with the pathogenesis and development of endometral adenocarcinoma. p21ras and p53 can be used as the reference for the diagnosis of endometral adenocarcinorna.
出处
《诊断病理学杂志》
CSCD
1997年第3期147-148,共2页
Chinese Journal of Diagnostic Pathology
