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南非严重耐多药结核基因型的多样性 被引量：2

Genotypic diversity of extensively drug-resistant tuberculosis(XDR-TB) in South Africa
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摘要 背景:严重耐多药结核(XDR-TB)已成为结核病控制的新威胁,但对其流行病学尚不十分了解。目的:采用分子手段研究南非XDR-TB菌株基因型的人群结构组成,从而确定XDR-TB主要是获得性还是原发感染。方法:收集耐多药结核(MDR-TB)患者的痰菌分离株,送至国家参比实验室进行二线抗结核药物的药敏试验。对XDR-TB的分离株进行Spoligotyping分型,并与该分离株的地理来源相匹配。结果:自2005年6月至2006年12月共获得699例MDR-TB患者的分离株,其中101例(17%)菌株耐氧氟沙星(OFX)或卡那霉素(KAN),41例(6%)对二者均耐药(XDR-TB)。Spoligotyping法将XDR-TB分离株共分为17个基因型。结果表现为高度的基因型多样性和地理分布多样性,所以我们估计63%～75%的XDR-TB患者为获得性耐药。结论:获得性严重耐多药可能是导致南非XDR-TB流行的主要机制。因此结核病控制的迫切问题是必须致力于阻止这种潜在的不治之症的传播。
作者 C.K.Mlambo R.M.Warren X.Poswa T.C.Victor A.G.Duse E.Marais 郑晓静（译） 张宗德（译） 何广学（审校）
机构地区 Clinical Microbiology and Infectious Disease Department of Science and Technology/National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research Tuberculosis Referral Laboratory 不详
出处 《国际结核病与肺部疾病杂志》 2008年第3期106-111,共6页 The International Journal of Tuberculosis and Lung Disease
基金 supported by the South African Medical Research Council the National Health Laboratory Services Research Trust and the University of the Witwatersr and Health Sciences Faculty Research Committee
关键词 分枝杆菌 结核 MDR—TB XDR—TB
分类号 R450 [医药卫生—治疗学] R52 [医药卫生—内科学]
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参考文献10

  • 1World Health Organization,International Union Against Tuberculosis and Lung Disease.Anti-tuberculosis drug resistance in the world. http://www,who.int/tb/publications/who_htm_ tb_2004_343/en/ . 2004
  • 2Holtz T H,Lancaster J,Laserson K F,et al.Risk factors associated with default from multidrng-resistant tuberculosis treatment,South Africa,1999-2001[].International Journal of Tuberculosis and Lung Disease.2006
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同被引文献2

  • 1Erik C. B?ttger,Burkhard Springer. Tuberculosis: drug resistance, fitness, and strategies for global control[J] 2008,European Journal of Pediatrics(2):141～148
  • 2S. M. Blower,Julie L. Gerberding. Understanding, predicting and controlling the emergence of drug-resistant tuberculosis: a theoretical framework[J] 1998,Journal of Molecular Medicine(9):624～636

引证文献2

二级引证文献5

国际结核病与肺部疾病杂志
2008年 第3期

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