摘要
目的评价老年晚期非小细胞肺癌（NSCLC）患者接受以铂类为基础的两药联合化疗的疗效和安全性。方法对我院41例年龄≥70岁的老年晚期NSCLC患者应用以铂类为基础的两药联合方案化疗的情况进行了回顾性分析。结果41例患者中采用长春瑞滨方案的18例（43．9％），吉西他滨方案的9例（22．0％）、紫杉醇和多西紫杉醇方案各7例（17．1％）。全组总有效率为19．5％，中位疾病进展时间和中位生存期分别为5．8个月和14．2个月，1年生存率为65．8％。化疗的主要不良反应为骨髓抑制，主要以白细胞和血小板减低为主，给予对症处理后可以恢复。患者无化疗相关死亡发生，有3例患者因出现Ⅲ～Ⅳ度骨髓抑制仅化疗1个周期。结论以铂类为基础的联合化疗方案治疗一般状况较好的老年晚期NSCLC疗效确切且耐受性较好。
Objective To evaluate the efficacy and safety of platinum-based chemotherapy in elderly patients with advanced non-small cell lung cancer（NSCLC） . Methods Clinical data of forty -one elderly patients （≥ 70 years） with advanced NSCLC who were treated by platinum based chemotherapy were analyzed retrospectively. Results Among the 41 patients, 18 （43.9%） patients were treated with vinorelbine, 9 （22.0%） patients with gemcitabine, 7 （17. 1%） patients with paclitaxel and docetaxel respectively. The overall response rate was 19.5%. The median time to progression （MTTP） was 5.8 months, and i-year survival rate was 65.8% with a median survival time （MST） of 14.2 months. No significant statistical differences were found among the four regimens. The major side effect was bone marrow suppression. Three patients withdrew chemotherapy after one cycle due to grade Ⅲ-Ⅳ myelosuppression. There was no death associated with chemotherapy. Conclusions The platinum-based combined chemotherapy is effective and welltolerated in elderly patients with advanced NSCLC.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2008年第11期801-804,共4页
Chinese Journal of Geriatrics
关键词
癌
非小细胞肺
抗肿瘤联合化疗方案
铂化合物
Carcinoma, non-small cell lung
Antineoplastic combined chemotherapy protocols
Platinum compounds
